COVID-19 Research at PHRI

PHRI was quick to design and implement clinical trials and studies to address the COVID-19...

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PHRI 20th Anniversary Symposium

At The Future of Global Health: PHRI’s 20th Anniversary Symposium, held November 2019, a total...

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PHRI International Fellows

PHRI Senior International Fellows, and PHRI International Fellows, are highly productive, independent researchers who have extensively collaborated with, or trained for several years at, PHRI.

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PHRI International

PHRI’s long-standing collaborations with a global network have resulted in many research successes. Until now,...

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PHRI Brain Health Initiative

PHRI has extensive experience in clinical trials aimed at treatment of vascular risk factors and...

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AF-SCREEN International Collaboration

More than 150 experts in atrial fibrillation (AF) from 37 countries – including four cardiologists and cardiac electrophysiologists from PHRI – collaborate to: promote discussion and research about screening for unknown or under-treated AF as a way to reduce stroke and death; investigate the role of AF detection technologies and implementation in health systems for AF screening (tailored to the medical systems of individual countries); and the role of oral anticoagulant therapy to prevent stroke in individuals found to have previously unknown AF.

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AF-SCREEN International Collaboration

PHRI studies within AF-SCREEN have included ASSERT III, PIAAF-Pharmacy, PIAAF-FP, and PIAAF-Home (Screen AF).

The Steering Committee of AF-SCREEN includes PHRI’s Jeff Healey; AF-SCREEN members also include PHRI’s David Conen, Stuart Connolly and William McIntyre.

Membership extends beyond cardiologists and cardiac electrophysiologists to include neurologists, geriatricians, epidemiologists, health economists, general and primary care physicians, nurses, pharmacists, physiotherapists, and patient advocates.

Partners of AF-SCREEN include C-SPIN, and several pharmaceutical and cardiac device companies.

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CoHESIVE

The Canadian Hemorrhagic Stroke Trials Initiative (CoHESIVE) is a Canada-wide multidisciplinary network of collaborators created in 2017 to improve our understanding of bleeding in the brain and the resulting mechanisms of brain injury and recovery; develop proven prediction tools and prevention and recovery strategies for hemorrhagic stroke, and effective acute treatments aimed at minimizing brain injury; and address risk:benefit analysis of using blood-thinning and cholesterol-lowering medications in patients with hemorrhagic stroke.

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CoHESIVE

The Executive Team of CoHESIVE includes (chair) Ashkan Shoamanesh as well as his PHRI colleagues Robert Hart, Stuart Connolly, John Eikelboom, Jeff Healey, Gui Paré and Mike Sharma; and various universities across Canada and Internationally, and the Heart and Stroke Foundation of Canada.

CoHESIVE is sponsored by several pharmaceutical and medical devices companies, and supported by the Canadian Stroke Trials for Optimized Results (CaSTOR) – a joint initiative of the Canadian Stroke Consortium and HSF Canadian Partnership for Stroke Recovery.

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Canadian Stroke Prevention Intervention Network (C-SPIN)

Founded in October 2013 and led by PHRI Senior Scientist, Jeff Healey, the C-SPIN network links researchers from across Canada in medicine, surgery, nursing, pharmacy, population health, and social sciences. With substantial support of the Canadian Institutes of Health Research, the Heart and Stroke Foundation of Canada and several pharmaceutical and cardiac device industry partners.

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Canadian Stroke Prevention Intervention Network (C-SPIN)

C-SPIN supports clinical trials aimed at finding innovative ways to prevent stroke among individuals with atrial fibrillation. C-SPIN also supports recruitment and retention of the next generation of Canadian clinical researchers in this field.

PHRI studies within C-SPIN include ARTESiA, NAVIGATE ESUS, LAAOS III, and C-CUSP (ED).

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IMAGINE-SPOR Chronic Disease Network

Network on Inflammation, Microbiome, and Alimentation: Gastro-Intestinal and Neuropsychiatric Effects: A large cohort of patients with Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD) and healthy controls. Patient information is gathered using validated questionnaires, and stool, urine and blood samples, to correlate gastrointestinal and psychological symptoms with their diet, microbiome and its metabolome.

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IMAGINE-SPOR Chronic Disease Network

IMAGINE-SPOR is led by Paul Moayyedi, PHRI senior scientist and gastroenterologist with McMaster University’s Dept. of Medicine. Program management for the network is provided by Tara McCready, Program Director, PHRI.

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ONTARIO BARIATRIC NETWORK (OBN)

To assist in developing evidence-based information regarding the risks and benefits of surgical and non-surgical treatments of obesity. OBN comprises two distinct components: the referral portal system; and the bariatric registry database, the latter of which is funded by the Ontario Ministry of Health and Long Term Care.

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ONTARIO BARIATRIC NETWORK (OBN)

OBN is led by Mehran Anvari, Scientific Director and CEO, Centre for Surgical Invention & Innovation (CSii), and is affiliated with McMaster University and St. Joseph’s Healthcare in Hamilton, Canada.

PHRI is the data management centre of the OBN, and coordinates the provincial bariatric registry.

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Chanchlani Research Centre

Established in 2011 by Vasu and Jaya Chanchlani, the Chanchlani Research Centre, at McMaster University, works in the areas of "omics" (genomics, proteonomics etc.) led by Sonia Anand.

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Chanchlani Research Centre

Featured projects include the nutrition, metabolomics and genomics in the birth cohorts project, Genetics of Opiod Addiction (GENOA), and the contextual map analysis of Canadian communities as part of the Canadian Alliance of Healthy Hearts and Minds (CAHHM) led by PHRI.

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McMaster Centre for Metabolism, Obesity and Diabetes Research

The McMaster Metabolism, Obesity and Diabetes Research (MacMODR) Centre is co-directed by Gregory Steinberg, Canada Research Chair in Metabolism and Obesity, and Katherine Morrison, pediatrician at McMaster and Associate Scientist at PHRI. Hertzel Gerstein, Deputy Director of PHRI, acts as Senior Advisor of MacMODR.

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McMaster Centre for Metabolism, Obesity and Diabetes Research

Katherine Morrison was Principal Investigator of the PHRI-sponsored, 8-year-Canadian Pediatric Weight Management Registry (CANPWR) that enrolled and monitored 1320 children to characterize the metabolic and psychosocial comorbidities, identify the determinants of these comorbidities, and examine whether these abnormalities change over time.

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Farncombe Family Digestive Health Research Institute

The Farncombe Family Digestive Health Research Institute (FFDHRI) is an integrated group of clinical and basic scientists focused on developing new strategies for the diagnosis, treatment and prevention of intestinal diseases such as Crohn’s disease and ulcerative colitis, and researching diseases of other organ systems that may be influenced by digestive health and nutrition.

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Farncombe Family Digestive Health Research Institute

FFDRI is led by gastroenterologist and Distinguished Professor at McMaster, Stephen Collins. Their Director of Clinical Research, Paul Moayyedi, is an Associate Scientist with PHRI, investigating how digestive health and nutrition affect disease, such as the IMAGINE-SPOR Network, a large observational cohort seeking better targeted treatment of people with irritable bowel syndrome and inflammatory bowel disease.

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Thrombosis & Atherosclerosis Research Institute

Founded in 1988 as the Henderson Research Centre, renamed TaARI in 2010, the institute's mission is to reduce death and disability from thrombotic diseases by conducting research into the pathogenesis, prevention, diagnosis and treatment of thrombosis and vascular disease.

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Thrombosis & Atherosclerosis Research Institute

TaARI, led by Jeff Weitz, shares space with PHRI in the David Braley Research Institute building. PHRI’s Gui Pare, Sonia Anand, John Eikelboom, and Hertzel Gerstein collaborate with TaARI on the themes of experimental thromobosis and atheroscelerosis, and in clinical thromboembolism programs.

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Firestone Institute for Respiratory Health

FIRH conducts research to increase understanding of respiratory health and disease through collaborative basic and clinical investigations - from basic studies of animal models of lung disease (asthma, COPD, fibrosis) to clinical trials and epidemiological studies.

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Firestone Institute for Respiratory Health

FIRH is led by Martin Kolb at St. Joseph’s Healthcare in Hamilton, and affiliated with McMaster University. Founded in 1979, the institute conducts basic and clinical research into airway inflammation, asthma, COPD, and other areas. PHRI collaborates with investigators in respiratory research, such as MyLinh Duong, to lead the world’s largest study in lung health.

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Escarpment Cancer Research Institute

Launched officially in 2011 as a joint McMaster University/Hamilton Health Sciences institute, the Escarpment Cancer Research Institute (ESCRI) conducts clinical trials as well as quality health care and knowledge translation in cancer.

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Escarpment Cancer Research Institute

The ESCRI is led by founding Scientific Director, Mark Levine is Chair and Professor in the Department of Oncology, McMaster University. PHRI scientists collaborate with ECRI to develop studies in cardio-oncology and cancer epidemiology.

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