Brain Health and Stroke

Robert Hart

Senior Scientist

Robert Hart is Professor of Medicine (Neurology) at McMaster University and a vascular neurologist at Hamilton Health Sciences. After completing a fellowship in cerebrovascular disease at the Oregon Health Sciences University, he spent most of his career at the University of Texas Health Science Center in San Antonio before relocating to McMaster University in September 2011.

He has a long-standing interest in stroke, stroke research, and clinical trials. He has directed several randomized clinical trials serving as the principal investigator of the NIH/NINDS-sponsored Stroke Prevention in Atrial Fibrillation (SPAF) I, II and III trials (1987-2000) and co-principal investigator of the NIH/NINDS-sponsored Secondary Prevention of Small Subcortical Strokes (SPS3) randomized trials (2001-2013). Antithrombotic therapies to prevent stroke in atrial fibrillation and especially novel oral anticoagulants are areas of special interest. He has published more than 250 articles in peer-reviewed journals.

Pierre Amarenco

Senior Scientist

A Professor of Neurology at Paris University in Paris, France, Pierre Amarenco is the founder of the department of Neurology and Stroke Center as well as of SOS-TIA clinic at Bichat university hospital in Paris.

His academic work has been in stroke prevention. He has published more than 450 research papers, reviews and book chapters; with significant contributions to the descriptions of cerebellar infarction, aortic arch atherosclerosis as a cause of stroke, and genetic and metabolic risk factors for stroke.

He has contributed to the leadership of major trials including SPARCL, Treat Stroke to Target, ARCH, XANTUS, SOCRATES, THALES, SPIRE, PROMINENT, RIISC and THETIS trials involving antithrombotics and lipid lowering agents as well as acute intracranial revascularization (RECANALISE). He’s led TIAregistry.org which resulted in insights into the outcomes of patients presenting with TIA, and is involved in the validation of new targets in animal models of ischemic stroke.

Stuart Connolly

Senior Scientist

Stuart Connolly is a Professor of Medicine at McMaster University and a cardiac electrophysiologist at Hamilton Health Sciences. He became a faculty member at McMaster University in 1983 and was awarded a full professorship in 1994. He was also appointed as the inaugural holder of the Salim Yusuf Chair in Cardiology at McMaster University.

He has published more than 270 scientific articles in the field, and is currently a member of the editorial boards for a number of prominent cardiology journals, including Heart, the American Heart Journal and the Journal of Pacing and Electrophysiology. His main research interests are focused on the evaluation of treatments for heart rhythm disorders. His academic career has been largely devoted to the design and execution of controlled clinical trials in this area.

He holds a Masters degree from Fordham University, New York, and an MD from McGill University in Montreal. He received his specialist training in cardiology at the University of Toronto and at Stanford University.

Mike Sharma

Scientist

Mike Sharma, MD MSc FRCPC, is the Director of the Stroke Program at McMaster University and Hamilton Health Sciences and holds the Michael G DeGroote Chair in Stroke Prevention, at McMaster University in Hamilton, Canada. His research interests include the development of new antithrombotic treatments, incorporating magnetic resonance imaging endpoints into the design of stroke prevention trials and examining the effects of anticoagulants on stroke recurrence and covert brain infarcts.

He has led trials and sub-studies in large prevention trials focused on these areas including COMPASS MIND, NAVIGATE ESUS, DATAS II and currently leads as principal investigator, the global phase II AXIOMATIC-SSP trial investigating FXI inhibition for stroke prevention in 27 countries.

He has published more than 140 articles in referred journals, is the immediate past Chair of the Canadian Stroke Consortium, the professional organization for stroke physicians and clinical trialists in Canada and established the stroke program at the University of Ottawa. Dr. Sharma is committed to developing integrated processes for stroke care and developing human and system capacity for the next generation of stroke trials.

Ashkan Shoamanesh

Scientist

Ashkan Shoamanesh is the founding Director, Hemorrhagic Stroke Research Program and Scientist, at PHRI, Assistant Professor of Medicine (Neurology), McMaster University,  and Director, Stroke Fellowship Program at Hamilton Health Sciences and McMaster. He is the inaugural Marta and Owen Boris Chair in Stroke Research and Care at McMaster. His research is focused on improving the clinical care of patients with stroke or who are at risk for stroke resulting from blood vessel rupture and bleeding into the brain.He is the founding Chair of the Canadian Hemorrhagic Stroke Trials Initiative (CoHESIVE) and leads as principal investigator the global phase III ENRICH-AF trial investigating optimal stroke prevention in intracranial hemorrhage survivors with atrial fibrillation in 22 countries.

He has been awarded the most prestigious early career awards in stroke granted by the American Heart/Stroke Association (2015 Mordecai Y.T. Globus and 2019 Robert G. Siekert New Investigator Awards in Stroke), American Academy of Neurology (2020 Michael S. Pessin Stroke Leadership Prize), and Heart and Stroke Foundation of Canada (2019 Henry J.M. Barnett Scholarship – recognizing the highest ranked National New Investigator in cerebrovascular disease research), amongst other notable awards, including the 2019 International Stroke Conference Paul Dudley White International Scholar Award and the 2014 European Stroke Conference Young Investigator Award.

Raed Joundi

Investigator

Raed Joundi is a stroke neurologist at Hamilton Health Sciences, Assistant Professor in the Department of Medicine (Division of Neurology) at McMaster University, and Investigator in the Brain Health research program at PHRI. His main academic interest is in evaluating and finding novel strategies to improve functional outcomes, quality of life, and cognition in people with cerebrovascular disease.

He obtained his undergraduate degree from the University of Manitoba, MD from Queen’s University, DPhil from Oxford University on a Rhodes Scholarship, and neurology residency training at the University of Toronto. He then completed a stroke fellowship and MSc in Clinical Epidemiology at the University of Calgary supported by a CIHR Fellowship Grant.

Aristeidis Katsanos

Investigator

Aristeidis Katsanos is a neurologist at Hamilton Health Sciences, and a stroke/vascular neurology fellow at McMaster University/HHS. His academic focus is on the evidence-based evaluation of novel therapeutic approaches on acute stroke treatment and secondary stroke prevention. His research study on optimal blood pressure management after endovascular stroke treatment (DETECT) is supported by the New Investigator Fund from HHS.

He obtained his MD and PhD degrees from the University of Ioannina in Greece. After finishing his training in neurology, he completed a research fellowship at the Ruhr University of Bochum in Germany granted by the European Academy of Neurology. Aristeidis has actively participated in numerous research projects and international collaborations and serves in the editorial board of several academic medical journals, including Stroke.

Kanjana Perera

Investigator

Kanjana (Sashi) Perera is an Investigator in the Brain Health research program at PHRI, Assistant Professor, Medicine (neurology), McMaster University, and a stroke neurologist at Hamilton Health Sciences. Her main research focus is on secondary stroke prevention, cryptogenic stroke, and uncommon causes of stroke and the optimization of clinical care in this patient population.

She has served as Principal Investigator and Co-Investigator for Phase II and III clinical trials, and is on the adjudication committees for international multicenter stroke/cardiovascular trials. She has won research awards, and her work has been published in high-impact medical journals. She obtained her medical degree from Sri Lanka with Honors for academic excellence. She completed her training in Neurology at the University of Western Ontario in 2013 and subsequently pursued a fellowship in Stroke/Vascular Neurology at McMaster University.

Jackie Bosch

Investigator

Jackie Bosch started working with Salim Yusuf in 1993, before PHRI was formally created, as she was completing her Masters in Clinical Epidemiology, with the intent to learn how to do clinical trials so she could run trials in post-stroke rehabilitation. Most recently, she has been a co-investigator on large trials in primary and secondary prevention of cardiovascular disease and diabetes, as well as understanding the causes of functional decline as well as developing simple, internationally applicable interventions to improve post-stroke disability.

She is Assistant Dean of the Occupational Therapy program, School of Rehabilitation Sciences, McMaster University, and has received awards such as the (McMaster) President’s Award for Outstanding Service, and the PHRI Award for Outstanding Contributions to Global Collaborations. She has more than 65 peer-reviewed publications.

Danielle de Sa Boasquevisque

Associate Research Fellow

Danielle de Sa Boasquevisque is an Associate Research Fellow at PHRI, supervised by Ashkan Shoamanesh, and is pursuing a Masters in Health Research Methodology at McMaster University. At PHRI, she is a co-Investigator in the ENRICH-AF trial and Project Officer for the CATIS-ICAD trial.

She obtained her MD from Federal University of Espirito Santo in Brazil and has completed internal medicine and neurology training in Sao Paulo, Brazil. In 2018, she completed her MSc in Neuroscience at Albert Einstein Institute/Sao Paulo, Brazil where she studied safety of transcranial direct current stimulation in patients after ischemic stroke. She also pursued a two-year clinical Stroke fellowship at McMaster University from 2018 to 2020.

Danielle has research interests in vascular neurology including acute stroke, neuro-rehabilitation, intracranial atherosclerotic disease and intracerebral hemorrhage. She is currently implementing an ICH cohort study and performing systematic review regarding ICH related outcomes.

Eric Smith

Associate Scientist

Eric Smith is a Professor of Clinical Neurosciences, and the Katthy Taylor Chair in Vascular Dementia in the Department of Clinical Neurosciences, University of Calgary, and Hotchkiss Brain Institute, and a member of the Calgary Stroke program. His research program has three main components: Population studies of brain health, using neuroimaging to identify predictors of cognitive impairment and decline; biomarker studies in patients with cognitive impairment, Alzheimer’s disease and cerebral amyloid angiopathy; and quality improvement and health outcomes research in patients with stroke and intracerebral hemorrhage. His research has been funded by the Canadian Institutes for Health Research, Heart and Stroke Foundation of Canada, Alberta Innovates – Health Solutions, Canadian Stroke Network, and the U.S. National Institute of Neurological Disorders and Stroke.

He received his MD degree from McGill University in 1998 and completed a residency in Neurology at Massachusetts General Hospital and Brigham and Women’s Hospital, teaching hospitals of Harvard Medical School. A one-year fellowship in Stroke and Vascular Neurology was completed at Massachusetts General Hospital in 2003. He earned a Master of Public Health degree (MPH) from the Harvard School of Public Health in 2005.

Amanda Taylor

Associate Program Manager

Amanda Taylor is an Associate Program Manager who currently coordinates trials in stroke, and has experience conducting trials in acute coronary syndrome and arrhythmia. Amanda joined PHRI in 2007. She holds a Bachelor of Science Degree (Honours) in Neurobiology from Brock University.

Jodi Miller

Project Manager

Jodi Miller has more than 15 years experience in academic research. She has been at PHRI since 2012 where she has coordinated large international industry and investigator initiated trials. In her current role she coordinates clinical trials and clinical quality assurance projects in stroke.

Jodi has a BSc in Physics from Mount Allison University and a PhD in Medical Biophysics with a focus on magnetic resonance imaging applications from Western University.

Kevin Reeh

Project Manager

Kevin Reeh has worked in research since 2008; starting with PHRI in 2014, Kevin began with the COMPASS trial study team. Kevin continues to coordinate global randomized multicenter trials in his current role with ENRICH-AF. Kevin has bachelor degrees in the Biological Sciences and Health Sciences, as well as a Masters of Science.