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Cancer Survivorship Research

PHRI is investigating the health of patients with cancer, or with cardiovascular complications resulting from treatments for cancer.

We are collaborating with leading oncology researchers including Chris Hillis, Som Mukherjee, Bindi Dhesy-Thind, Jehonathan Pinthus, Himu Lukka, Nazanin Aghel, Bobby Shayegan, and Dina Khalaf.

Team Members in Cancer Survivorship

Darryl Leong

Scientist

Darryl Leong
Scientist

Darryl Leong is a Scientist at PHRI, Director of the McMaster University and Hamilton Health Sciences Cardio-Oncology Program, Associate Professor, Department of Medicine (Cardiology), McMaster University, and Staff Cardiologist at Hamilton Health Sciences. He has methodological expertise in clinical epidemiology and clinical trials, and content expertise in physical frailty, echocardiography, and cardio-oncology. His research is supported by the CIHR, and he has published more than 100 manuscripts including all the leading internal medical and cardiovascular journals.

He graduated from the University of Adelaide Medical School with Deans Listing and Honours for academic excellence, completed his cardiology training, Doctor of Philosophy, Master of Public Health, and Master of Biostatistics degrees at the University of Adelaide in Australia, and completed a post-doctorate fellowship in cardiovascular imaging at the Leiden University Medical Centre in The Netherlands, before re-locating to Canada.

PJ Devereaux

Senior Scientist

PJ Devereaux
Senior Scientist

PJ Devereaux is Senior Scientific Lead, Perioperative and Surgery, PHRI, Professor and University Scholar in the Departments of Health Research Methods, Evidence, and Impact (HEI) and Medicine at McMaster University, and Director of the Division of Cardiology at McMaster.

The focus of his clinic research is vascular complications around the time of surgery, leading several large, international RCTs and observational studies addressing this issue. He has published more than 250 peer-reviewed papers and more than 50 book chapters and editorials. He is supported by a Tier 1 Canadian Research Chair in Perioperative Medicine, and holds the Yusuf Chair in Cardiology at McMaster University.

David Conen

Scientist

David Conen
Scientist

David Conen is an investigator at PHRI, and Associate Professor, Medicine, McMaster University. A clinical cardiologist with training in performing echocardiography, David’s research involves the conduct of large epidemiological cohort studies to study risk factors for the occurrence of atrial fibrillation and its consequences. He is also interested in clinical trials on therapies to prevent atrial fibrillation and the complications associated with the arrhythmia.

He received numerous prestigious grants in Switzerland and is the Principal Investigator of a large national cohort study to assess the relationship between atrial fibrillation and cognitive decline (Swiss-AF). He also leads another large cohort study of young and healthy individuals (GAPP), with a key focus on assessing risk factors for the development of cardiovascular risk factors in the general population.

Deborah Siegal

Scientist

Deborah Siegal
Scientist

Deborah Siegal is Assistant Professor, Division of Hematology and Thromboembolism, McMaster University, as well as Scientist in the Thrombosis program at PHRI. Her primary research interests include: improving patient outcomes after anticoagulant-related bleeding; emergency management of anticoagulants for acute bleeding or urgent surgery; understanding the factors that influence patient and physician decision-making after anticoagulant-related bleeding; and reducing red blood cell transfusion by minimizing iatrogenic blood loss for laboratory testing. She has expertise in the design and conduct of pragmatic cluster randomized trials, individual patient randomized trials, mixed-methods studies, observational studies, and meta-analyses.

She has received peer-reviewed grant support as principal investigator from the American Society of Hematology, CanVECTOR/Heart and Stroke Foundation of Canada, Ontario AFP Innovation Fund, and Hamilton Health Sciences Foundation. She has published over 60 articles in high-impact peer-reviewed journals including The New England Journal of Medicine. Deborah graduated from Queen’s University School of Medicine in 2009, and completed Internal Medicine and Hematology training at McMaster University. She holds Master of Science degrees in Pharmacology (University of Toronto) and Health Research Methodology (McMaster University).

Sumathy Rangarajan

Program Director

Sumathy Rangarajan
Program Director

Sumathy Rangarajan has been Program Director, Global Health, since 2016, preceded by many years’ service at PHRI in other roles. She oversees the PURE study team, as well as the INVICTUS rheumatic AF treatment trial, the CANPWR pediatric weight management registry, and others.

She holds both a Bachelor of Science Degree and a Master of Science degree from Pune University in India.

ongoing

ORCHID

Cancer Survivorship

The Ontario Registry of CHronic Myeloproliferative Neoplasms and Incident Cardiovascular Disease (ORCHID) / Inflammation in...

ongoing

PURE-ICE

Cancer Survivorship

Major improvements in the prevention and early detection of cancer will require new approaches to...

ongoing

RADICAL PC-Interventional

Cancer Survivorship

RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate...

ongoing

RADICAL PC-Observational

Cancer Survivorship

RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate...

ongoing

SCHOLAR 2

Cancer Survivorship

The objective of the SCHOLAR-2 study is to evaluate whether is it safe and effective...

completed

SCHOLAR

Cancer Survivorship

Trastuzumab has been shown to improve survival in individuals with early stage HER-2 positive breast...

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