Major improvements in the prevention and early detection of cancer will require new approaches to understand how cancers develop, and to identify those at very high risk of future cancer.

The objective of the substudy, PURE-ICE (International Cancer Epidemiology) is to identify and describe phenotypes (a cluster of characteristics, including lifestyle and dietary factors) of middle-aged adults associated with an increased risk of developing common cancers.

In this analysis of the Prospective Urban Rural Epidemiology (PURE) study, the PURE-ICE team aims to bring together:

  • The large amount of baseline data collected from PURE participants;
  • The development of cancer in more than 5,000 participants during 10 years of follow-up; and
  • The potential of Machine Learning to identify new patterns of cancer risk factors.
Study Type


Study Design

Prospective cohort

NO. of Countries


NO. of Sites


NO. of Participants


Study Period

2020 - 2022



Cancer Research Society

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