The Ontario Registry of CHronic Myeloproliferative Neoplasms and Incident Cardiovascular Disease (ORCHID) / Inflammation in Myeloproliferative Philadelphia Chromosome Negative Neoplasms – Relationship with Biomarkers of Disease Activity (IMPACT) is a multi-centre prospective observational registry of patients with chronic myeloproliferative neoplasms (MPN) recruited within one year of diagnosis.

The registry’s goal is to inform the epidemiology and course of MPNs in the contemporary context.

Specifically, as MPN survival improves, and with the advent of treatments that may have cardiovascular adverse effects, there is a need to better understand the evolving epidemiology of MPNs.

The creation of this registry will inform the true incidence of vascular disease in the Tyrosine Kinase Inhibitors (TKI) treated Chronic Myeloid Leukemia (CML), Polycythemia vera (PV), Primary myelofibrosis (PMF) and Essential Thrombocytosis (ET) patient populations.

Study Type

Registry - Observational

Study Design

Multi-center prospective

NO. of Countries


NO. of Sites

5 target

NO. of Participants

1500 target

Study Period




Hamilton Health Sciences

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