Registry - Observational
The Ontario Registry of CHronic Myeloproliferative Neoplasms and Incident Cardiovascular Disease (ORCHID) / Inflammation in Myeloproliferative Philadelphia Chromosome Negative Neoplasms – Relationship with Biomarkers of Disease Activity (IMPACT) is a multi-centre prospective observational registry of patients with chronic myeloproliferative neoplasms (MPN) recruited within one year of diagnosis.
The registry’s goal is to inform the epidemiology and course of MPNs in the contemporary context.
Specifically, as MPN survival improves, and with the advent of treatments that may have cardiovascular adverse effects, there is a need to better understand the evolving epidemiology of MPNs.
The creation of this registry will inform the true incidence of vascular disease in the Tyrosine Kinase Inhibitors (TKI) treated Chronic Myeloid Leukemia (CML), Polycythemia vera (PV), Primary myelofibrosis (PMF) and Essential Thrombocytosis (ET) patient populations.
Registry - Observational
Darryl Leong is a Scientist at PHRI, Director of the McMaster University and Hamilton Health Sciences Cardio-Oncology Program, Associate Professor, Department of Medicine (Cardiology), McMaster University, and Staff Cardiologist at Hamilton Health Sciences. He has methodological expertise in clinical epidemiology and clinical trials, and content expertise in physical frailty, echocardiography, and cardio-oncology. His research is supported by the CIHR, and he has published more than 100 manuscripts including all the leading internal medical and cardiovascular journals.
He graduated from the University of Adelaide Medical School with Deans Listing and Honours for academic excellence, completed his cardiology training, Doctor of Philosophy, Master of Public Health, and Master of Biostatistics degrees at the University of Adelaide in Australia, and completed a post-doctorate fellowship in cardiovascular imaging at the Leiden University Medical Centre in The Netherlands, before re-locating to Canada.
Deborah Siegal is an Associate Professor in the Department of Medicine within the Division of Hematology at the University of Ottawa. Her primary research interests include improving patient outcomes after anticoagulant-related bleeding; management of anticoagulants in patients who have acute bleeding complications or require urgent surgery; understanding the factors that influence patient and physician decision-making after anticoagulant-related bleeding; and reducing red blood cell transfusion by minimizing iatrogenic blood loss for laboratory testing.
With expertise in the design and conduct of pragmatic cluster randomized trials, individual patient randomized trials, mixed-methods studies, observational studies and meta-analyses, Deborah Siegal has received peer-reviewed grant support as principal investigator from the Canadian Institutes of Health Research, the American Society of Hematology, CanVECTOR/Heart and Stroke Foundation of Canada, Ontario AFP Innovation Fund, and Hamilton Health Sciences Foundation. She has published 70 peer-reviewed articles including several in high-impact journals such as The New England Journal of Medicine, Circulation, Blood, and Journal of Thrombosis and Haemostasis.
Sumathy Rangarajan has been Program Director, Global Health, since 2016, preceded by many years’ service at PHRI in other roles. She oversees the PURE study team, as well as the INVICTUS rheumatic AF treatment trial, the CANPWR pediatric weight management registry, and others.
She holds both a Bachelor of Science Degree and a Master of Science degree from Pune University in India.
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