PHRI has extensive experience in clinical trials aimed at treatment of vascular risk factors and prevention of vascular disease. A series of innovative studies aimed at understanding and preserving brain health include the assessment of global variations in dementia in a prospective study in 26 countries (the PURE study), elucidating the impact of environmental and lifestyle factors on dementia, and undertaking biomarker analyses to discover novel potential modifiable pathways that lead to cognitive decline and dementia.

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