Healthy Aging
There are many different facets to healthy aging; these facets are changing in recent decades, as we witness a major epidemiologic shift as the result of aging populations globally. PHRI researchers have been working for years in subjects including frailty, genetic and biomarker mapping of vulnerabilities, healthy mind, metabolic awareness, and more.
Learn MoreAccelerating Clinical Trials
ACT/AEC is a pan-Canadian clinical trials consortium brings together hundreds of researchers from 28 networks, 11 trial units, patient-partners, the biotechnology industry, government, and experts in research ethics review processes, contracts, insurance, regulatory processes, patient engagement, clinical trials training, communications, and knowledge mobilization.
Learn MoreIndigenous Health Research
Indigenous Peoples in Canada – First Nations, Metis and Inuit – have historically been under-represented in health research. An effort is underway by research organizations, including PHRI, to rectify this approach including consultation with Indigenous Peoples about their own health needs.
Learn MorePolypills for CVD Prevention
Polypills - also known as fixed-dose combination (FDC) therapy - have moved in the last 20 years from concept to substantial evidence of effectiveness for primary and secondary prevention of CVD.
Learn MoreDigital Health Research
Interacting with patients by computer, phone or apps, virtual healthcare can consist of: sharing patient...
Learn MoreCanadian Heart Function (CHF) Alliance
PHRI is a foundational partner in the Canadian Heart Function Alliance (CHF Alliance) network bringing together 132 Canadian researchers and clinical experts in heart failure, patients, and more.
Learn MoreSTRIVE
Strategic Translational Research In Vascular HEalth (STRIVE) Translational research, known as “bench to bedside, and...
Learn MoreTransforming Tomorrow Today
To further develop transdisciplinary research, PHRI is partnering with Hamilton Health Sciences (HHS) in a...
Learn MoreBiomarker Discovery Partnership Program
Led by Guillaume Paré, Director of CRLB-GMEL laboratory and a Senior Scientist at PHRI, and Salim...
Learn MoreCOVID-19 Research at PHRI
From the international ACT COVID-19 program, to a PURE sub-study, virtual care with remote patient monitoring
Learn MorePHRI 20th Anniversary Symposium
At The Future of Global Health: PHRI’s 20th Anniversary Symposium, held November 2019, a total...
Learn MorePHRI International Fellows
Highly productive, independent researchers who have extensively collaborated with or trained at PHRI
Learn MorePHRI International
PHRI’s long-standing collaborations with a global network have resulted in many research successes. Until now,...
Learn MorePHRI Brain Health Program
The PHRI Brain Health Program (BHP) focuses on defining new interventions for the treatment and...
Learn More
AF-SCREEN International Collaboration
More than 150 experts in atrial fibrillation (AF) from 37 countries – including four cardiologists and cardiac electrophysiologists from PHRI – collaborate to: promote discussion and research about screening for unknown or under-treated AF as a way to reduce stroke and death; investigate the role of AF detection technologies and implementation in health systems for AF screening (tailored to the medical systems of individual countries); and the role of oral anticoagulant therapy to prevent stroke in individuals found to have previously unknown AF.
AF-SCREEN International Collaboration
PHRI studies within AF-SCREEN have included ASSERT III, PIAAF-Pharmacy, PIAAF-FP, and PIAAF-Home (Screen AF).
The Steering Committee of AF-SCREEN includes PHRI’s Jeff Healey; AF-SCREEN members also include PHRI’s David Conen, Stuart Connolly and William McIntyre.
Membership extends beyond cardiologists and cardiac electrophysiologists to include neurologists, geriatricians, epidemiologists, health economists, general and primary care physicians, nurses, pharmacists, physiotherapists, and patient advocates.
Partners of AF-SCREEN include C-SPIN, and several pharmaceutical and cardiac device companies.
CoHESIVE
The Canadian Hemorrhagic Stroke Trials Initiative (CoHESIVE) is a Canada-wide multidisciplinary network of collaborators created in 2017 to improve our understanding of bleeding in the brain and the resulting mechanisms of brain injury and recovery; develop proven prediction tools and prevention and recovery strategies for hemorrhagic stroke, and effective acute treatments aimed at minimizing brain injury; and address risk:benefit analysis of using blood-thinning and cholesterol-lowering medications in patients with hemorrhagic stroke.
CoHESIVE
The Executive Team of CoHESIVE includes (chair) Ashkan Shoamanesh as well as his PHRI colleagues Robert Hart, Stuart Connolly, John Eikelboom, Jeff Healey, Gui Paré and Mike Sharma; and various universities across Canada and Internationally, and the Heart and Stroke Foundation of Canada.
CoHESIVE is sponsored by several pharmaceutical and medical devices companies, and supported by the Canadian Stroke Trials for Optimized Results (CaSTOR) – a joint initiative of the Canadian Stroke Consortium and HSF Canadian Partnership for Stroke Recovery.
Canadian Stroke Prevention Intervention Network (C-SPIN)
Founded in October 2013 and led by PHRI Senior Scientist, Jeff Healey, the C-SPIN network links researchers from across Canada in medicine, surgery, nursing, pharmacy, population health, and social sciences. With substantial support of the Canadian Institutes of Health Research, the Heart and Stroke Foundation of Canada and several pharmaceutical and cardiac device industry partners.
Canadian Stroke Prevention Intervention Network (C-SPIN)
C-SPIN supports clinical trials aimed at finding innovative ways to prevent stroke among individuals with atrial fibrillation. C-SPIN also supports recruitment and retention of the next generation of Canadian clinical researchers in this field.
PHRI studies within C-SPIN include ARTESiA, NAVIGATE ESUS, LAAOS III, and C-CUSP (ED).
IMAGINE-SPOR Chronic Disease Network
Network on Inflammation, Microbiome, and Alimentation: Gastro-Intestinal and Neuropsychiatric Effects: A large cohort of patients with Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD) and healthy controls. Patient information is gathered using validated questionnaires, and stool, urine and blood samples, to correlate gastrointestinal and psychological symptoms with their diet, microbiome and its metabolome.
IMAGINE-SPOR Chronic Disease Network
IMAGINE-SPOR is led by Paul Moayyedi, PHRI senior scientist and gastroenterologist with McMaster University’s Dept. of Medicine. Program management for the network is provided by Tara McCready, Program Director, PHRI.
ONTARIO BARIATRIC NETWORK (OBN)
To assist in developing evidence-based information regarding the risks and benefits of surgical and non-surgical treatments of obesity. OBN comprises two distinct components: the referral portal system; and the bariatric registry database, the latter of which is funded by the Ontario Ministry of Health and Long Term Care.
ONTARIO BARIATRIC NETWORK (OBN)
OBN is led by Mehran Anvari, Scientific Director and CEO, Centre for Surgical Invention & Innovation (CSii), and is affiliated with McMaster University and St. Joseph’s Healthcare in Hamilton, Canada.
PHRI is the data management centre of the OBN, and coordinates the provincial bariatric registry.
Chanchlani Research Centre
Established in 2011 by Vasu and Jaya Chanchlani, the Chanchlani Research Centre, at McMaster University, works in the areas of "omics" (genomics, proteonomics etc.) led by Sonia Anand.
Chanchlani Research Centre
Featured projects include the nutrition, metabolomics and genomics in the birth cohorts project, Genetics of Opiod Addiction (GENOA), and the contextual map analysis of Canadian communities as part of the Canadian Alliance of Healthy Hearts and Minds (CAHHM) led by PHRI.
McMaster Centre for Metabolism, Obesity and Diabetes Research
The McMaster Metabolism, Obesity and Diabetes Research (MacMODR) Centre is co-directed by Gregory Steinberg, Canada Research Chair in Metabolism and Obesity, and Katherine Morrison, pediatrician at McMaster and Associate Scientist at PHRI. Hertzel Gerstein, Deputy Director of PHRI, acts as Senior Advisor of MacMODR.
McMaster Centre for Metabolism, Obesity and Diabetes Research
Katherine Morrison was Principal Investigator of the PHRI-sponsored, 8-year-Canadian Pediatric Weight Management Registry (CANPWR) that enrolled and monitored 1320 children to characterize the metabolic and psychosocial comorbidities, identify the determinants of these comorbidities, and examine whether these abnormalities change over time.
Farncombe Family Digestive Health Research Institute
The Farncombe Family Digestive Health Research Institute (FFDHRI) is an integrated group of clinical and basic scientists focused on developing new strategies for the diagnosis, treatment and prevention of intestinal diseases such as Crohn’s disease and ulcerative colitis, and researching diseases of other organ systems that may be influenced by digestive health and nutrition.
Farncombe Family Digestive Health Research Institute
FFDRI is led by gastroenterologist and Distinguished Professor at McMaster, Stephen Collins. Their Director of Clinical Research, Paul Moayyedi, is an Associate Scientist with PHRI, investigating how digestive health and nutrition affect disease, such as the IMAGINE-SPOR Network, a large observational cohort seeking better targeted treatment of people with irritable bowel syndrome and inflammatory bowel disease.
Thrombosis & Atherosclerosis Research Institute
Founded in 1988 as the Henderson Research Centre, renamed TaARI in 2010, the institute's mission is to reduce death and disability from thrombotic diseases by conducting research into the pathogenesis, prevention, diagnosis and treatment of thrombosis and vascular disease.
Thrombosis & Atherosclerosis Research Institute
TaARI, led by Jeff Weitz, shares space with PHRI in the David Braley Research Institute building. PHRI’s Gui Pare, Sonia Anand, John Eikelboom, and Hertzel Gerstein collaborate with TaARI on the themes of experimental thromobosis and atheroscelerosis, and in clinical thromboembolism programs.
Firestone Institute for Respiratory Health
FIRH conducts research to increase understanding of respiratory health and disease through collaborative basic and clinical investigations - from basic studies of animal models of lung disease (asthma, COPD, fibrosis) to clinical trials and epidemiological studies.
Firestone Institute for Respiratory Health
FIRH is led by Martin Kolb at St. Joseph’s Healthcare in Hamilton, and affiliated with McMaster University. Founded in 1979, the institute conducts basic and clinical research into airway inflammation, asthma, COPD, and other areas. PHRI collaborates with investigators in respiratory research, such as MyLinh Duong, to lead the world’s largest study in lung health.
Escarpment Cancer Research Institute
Launched officially in 2011 as a joint McMaster University/Hamilton Health Sciences institute, the Escarpment Cancer Research Institute (ESCRI) conducts clinical trials as well as quality health care and knowledge translation in cancer.
Escarpment Cancer Research Institute
The ESCRI is led by founding Scientific Director, Mark Levine is Chair and Professor in the Department of Oncology, McMaster University. PHRI scientists collaborate with ECRI to develop studies in cardio-oncology and cancer epidemiology.
