Interventional - Drug
The objective of the RE-LY study was to demonstrate the efficacy and safety of dabigatran etexilate in patients with non-valvular atrial fibrillation for the prevention of stroke and systemic embolism.
Incidence of stroke (including hemorrhagic) and systemic embolism.
Incidence of stroke (including hemorrhagic); systemic embolism; all death; Incidence of stroke (including hemorrhagic); systemic embolism; pulmonary embolism; acute myocardial infarction; or vascular deaths (including deaths from bleeding).
All primary and secondary events are adjudicated.RE-LY Presentation - Download PDF
Interventional - Drug
Prospective, randomized, parallel-group, non-inferiority trial
Stuart Connolly is a Professor of Medicine at McMaster University and a cardiac electrophysiologist at Hamilton Health Sciences. He became a faculty member at McMaster University in 1983 and was awarded a full professorship in 1994. He was also appointed as the inaugural holder of the Salim Yusuf Chair in Cardiology at McMaster University.
He has published more than 270 scientific articles in the field, and is currently a member of the editorial boards for a number of prominent cardiology journals, including Heart, the American Heart Journal and the Journal of Pacing and Electrophysiology. His main research interests are focused on the evaluation of treatments for heart rhythm disorders. His academic career has been largely devoted to the design and execution of controlled clinical trials in this area.
He holds a Masters degree from Fordham University, New York, and an MD from McGill University in Montreal. He received his specialist training in cardiology at the University of Toronto and at Stanford University.
Associate Program Manager
Gayle Lewis joined PHRI’s Arrhythmia group in 2005 to work on the RE-LY trial; she started up the AVERROES trial in 2007, which she managed until its 2010 close. In 2012, Gayle moved to PHRI’s Global Health program, where she works on various epidemiological studies including PURE, as well as the rheumatic AF treatment study, INVICTUS.
Prior to joining McMaster University, she worked in Toronto at Digital Equipment of Canada for five years and was responsible for the development, testing, implementation and training of the Canadian Automatic Quoting system (AQS) for all Sales Representatives across Canada.
Gayle has been an employee of McMaster University since 1989 when she joined the Clinical Epidemiology & Biostatistics Group, and remained on campus until 1992, at which time she relocated to the Clinical Trials Methodology Group.
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