Observational - Registry
The objective of the RE-LY AF Registry was to evaluate and document the variations in the presentation and management of patients with atrial fibrillation (AF) across various geographies.
1. To determine variations in the predisposing conditions for atrial fibrillation and atrial flutter (AF/flutter) between different regions of the world and practice settings.
2. To document regional variations in the management of AF/flutter and associated cardiovascular disease, including the frequency of anti-thrombotic and anti-hypertensive therapy and the degree of INR control.
3. To document differences in the adverse cardiovascular outcomes of AF/flutter.
Observational - Registry
Jeff Healey is a Senior Scientist in the Arrhythmia and Heart Failure research program at PHRI, an Associate Professor, Medicine, McMaster University, and Director of Arrhythmia Services at Hamilton Health Sciences. His research involves conducting RCTs and large registries in the fields of atrial fibrillation and cardiac devices. He was the lead author of the SIMPLE trial, published in the Lancet in 2015, which demonstrated that implantable defibrillators could be safely inserted without performing intra-operative defibrillation testing.
He was the lead author of the ASSERT trial, published in New England Journal of Medicine in 2012, demonstrating the increased stroke risk associated with sub-clinical atrial fibrillation detected by pacemakers. Thomson-Reuters recognized ASSERT as the 38th most-cited scientific publication in 2012 (#16 in Medicine).
He was principal investigator and chair of the Canadian Stroke Prevention Intervention Network (CSPIN), a ten-year network grant funded by the Canadian Institutes of Health Research, The Heart and Stroke Foundation of Canada and Industry. He is the past co-chair of the Canadian Cardiovascular Society’s Atrial Fibrillation Guidelines Committee. Jeff has published more than 185 manuscripts.
PHRI International Fellow
Alexander Benz joined the Arrhythmia Research group at PHRI, supervised by Stuart Connolly, as a research fellow in January 2019, and is enrolled in the Health Research Methodology program at McMaster University. His primary research interest is clinical electrophysiology, with a particular focus on atrial fibrillation. Other areas of interest include oral anticoagulation in various settings, inflammation, cardiac implantable electronic devices and interventions such as catheter ablation.
He is actively involved in the conduct of large international clinical trials coordinated at PHRI. Alexander is the Principal Investigator of a randomized clinical trial testing a short-course treatment with colchicine in the setting of catheter ablation for atrial fibrillation that started enrollment in January 2020.
Alexander obtained his medical degree from Goethe University in Frankfurt (Germany) in 2015. He is pursuing a career in Cardiology.
Associate Program Manager
Ellison Themeles’ experience includes more than 20 years in the conduct, execution and management of large, international clinical trials involving both medical devices and pharmaceutical agents in the area of cardiovascular disease and arrhythmias.
She holds a Bachelor of Arts degree in Gerontology and Sociology, and a Master of Science Degree in Health Research Methodology, from McMaster University.
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