The objective of the HOPE-4 study was to develop, implement, and evaluate an evidence-based, contextually-appropriate programme for cardiovascular disease (CVD) risk assessment, treatment, and control involving:

  • Simplified algorithms implemented by non-physician health workers (NPHW) and supported by mobile (m-) health technologies (tablets programmed with decision and counselling support software); and;
  • Initiation of evidence-based cardiovascular medications, and;
  • Treatment supporters to optimize long-term medication and lifestyle adherence.

The HOPE-4 study team included:

  • Khalid Yusoff, Principal Investigator in Malaysia
  • Patricio Lopez-Jaramillo, Principal Investigator in Colombia
HOPE-4 ESC 2019 - Download PDF
Study Type

Interventional - Drug

Study Design

Parallel-group, community cluster RCT

NO. of Countries


NO. of Sites


NO. of Participants


Study Period

2014 - 2019



VIDEO: Patricio Lopez-Jaramillo (and JD Schwalm) on HOPE-4

Canadian Institutes of Health Research (CIHR)

Grand Challenges Canada

Global Alliance for Chronic Disease

Ontario Ministry of Health

Boehringer Ingelheim

Ontario SPOR Support Unit (OSSU)

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