The objective of the HOPE-4 study was to develop, implement, and evaluate an evidence-based, contextually-appropriate programme for cardiovascular disease (CVD) risk assessment, treatment, and control involving:

  • Simplified algorithms implemented by non-physician health workers (NPHW) and supported by mobile (m-) health technologies (tablets programmed with decision and counselling support software); and;
  • Initiation of evidence-based cardiovascular medications, and;
  • Treatment supporters to optimize long-term medication and lifestyle adherence.

The HOPE-4 study team included:

  • Khalid Yusoff, Principal Investigator in Malaysia
  • Patricio Lopez-Jaramillo, Principal Investigator in Colombia
HOPE-4 ESC 2019 - Download PDF
Study Type

Interventional - Drug

Study Design

Parallel-group, community cluster RCT

NO. of Countries


NO. of Sites


NO. of Participants


Study Period

2014 - 2019



VIDEO: HOPE 4 Colombia PI Patricio Lopez-Jaramillo (shown here) and lead PI JD Schwalm discuss the study

Canadian Institutes of Health Research (CIHR)

Grand Challenges Canada

Global Alliance for Chronic Disease

Ontario Ministry of Health

Boehringer Ingelheim

Ontario SPOR Support Unit (OSSU)

Back To Top