Interventional - Drug
The objective of the HOPE-2 study was to evaluate whether long term supplementation with folic acid, vitamins B6 and B12 aimed at homocyst(e)ine reduction reduces the rates of major fatal and nonfatal cardiovascular events in patients with established cardiovascular disease and/or diabetes mellitus.
At the time of its publication, the HOPE-2 study was the largest trial of homocysteine lowering B vitamins in CVD prevention.
The trial findings of no benefit for B vitamin supplementation influenced guidelines and patterns of practice worldwide.
Composite of CV death, myocardial infarction and stroke.
All-cause death, total ischemic events, revascularizations, hospitalization for heart failure, hospitalization for unstable angina, venous thromboembolism, incident cancer and cancer death.
All primary and secondary outcomes were adjudicated (except revascularizations).
Interventional - Drug
Randomized, double-blind, placebo control, safety/efficacy, parallel group design
Eva Lonn is a Principal Investigator for the Atherosclerosis Imaging and Cardiovascular Prevention programs at PHRI, and a Professor of Medicine in the Division of Cardiology at McMaster University.
She has led several large international trials and was a member of the International Steering Committee of additional landmark cardiovascular prevention trials. She directed the Vascular Research Ultrasound Laboratory at PHRI for more than 20 years. She served for many years on the Canadian Cardiovascular Society Council and Executive Committee. She has received research grants from the Medical Research Council of Canada, the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada. She published over 220 peer reviewed articles, and 8 book chapters.
After obtaining her medical degree from the Hebrew University in Jerusalem, Eva Lonn completed clinical training in Internal Medicine, Cardiology and Advanced Imaging at the University of Toronto and research fellowships at the University of Toronto and at McMaster University, where she obtained also a Master of Science degree in Health Research Methodology.
Jackie Bosch started working with Salim Yusuf in 1993, before PHRI was formally created, as she was completing her Masters in Clinical Epidemiology, with the intent to learn how to do clinical trials so she could run trials in post-stroke rehabilitation. Most recently, she has been a co-investigator on large trials in primary and secondary prevention of cardiovascular disease and diabetes, as well as understanding the causes of functional decline as well as developing simple, internationally applicable interventions to improve post-stroke disability.
She is Assistant Dean of the Occupational Therapy program, School of Rehabilitation Sciences, McMaster University, and has received awards such as the (McMaster) President’s Award for Outstanding Service, and the PHRI Award for Outstanding Contributions to Global Collaborations. She has more than 65 peer-reviewed publications.
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