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COP-AF Pilot Study

Official Title

COlchicine For Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF) Pilot Study

Status

Completed

Overview

Complications such as atrial fibrillation (AF) occur commonly after thoracic surgery and adversely affect patient outcomes and significantly increase health care costs. Effective prevention of these complications is expected to reduce the incidence of stroke while shortening length of hospital stay and re-admissions. Colchicine, an anti-inflammatory agent, has been effective in preventing perioperative AF and post-pericardiotomy syndrome in the cardiac surgery setting. We propose to undertake a pilot randomized control trial to determine the feasibility of using colchicine for the prevention of new onset AF in patients undergoing thoracic surgery.

Study Design

Randomized controlled, blinded, multicenter pilot trial.

Primary Endpoint

Determine the feasibility of recruiting patients undergoing thoracic surgery to an RCT of colchicine vs. placebo for the prevention of perioperative AF and establish the foundation for a large, multi-centre, clinical trial.

Number of Patients

100

Number of Sites

2

Number of Countries

1

Study Period

2013-2015

Principal Investigator

P.J. Devereaux

Program Manager

Shirley Pettit

Research Coordinator

Barbara Jedrzejowski