Biomarker and Genetic Analysis

Guillaume Paré

Director, CRLB- GMEL; Senior Scientist

Guillaume Paré is Director of the Clinical Research Laboratory and Biobank (CRLB) – Genetic and Molecular Epidemiology Laboratory (GMEL). He is also Deputy Director of the Thrombosis and Atherosclerosis Research Institute (TaARI), a Professor of Pathology and Molecular Medicine, a Professor in the Department of Health Research Methods, Evidence and Impact, and a University Scholar at McMaster University. He holds the Cisco Professorship in Integrated Health Biosystems.

His clinical interests are centered on lipoprotein disorders, obesity and cardiovascular disease prevention, with research interests in cardiovascular genetics, biomarker development and pharmacogenomics. Gui’s research combines high-throughput biomarker screens with genetics, bioinformatics and epidemiology to identify novel cardio-metabolic biomarkers. He has published more than 200 papers and has been cited over 27,000 times.

A medical biochemist with board certification from the Royal College of Physicians and Surgeons of Canada, Gui completed a Master’s in Human Genetics at McGill University under the supervision of renowned geneticist Thomas Hudson. He further trained in genetic epidemiology with Paul Ridker at Harvard Medical School.

Matthew McQueen

Deputy Director, CRLB-GMEL

Matthew McQueen co-founded the Clinical Research Laboratory and Biobank (CRLB) in Hamilton, Canada in 1987. As a physician and Director of the Lipid Research Clinic, his clinical focus has been on lipid disorders, primary and secondary prevention of cardiovascular disease, and the investigation of statins, fibrates, and probucol in reducing disease risk. He expanded his clinical research laboratory (then known as CRCTL) to provide analytical support for the large epidemiologic studies and clinical trials from PHRI. To date, he has been the author or coauthor of more than 250 publications.

He has retired as a Professor in the Department of Pathology and Molecular Medicine, McMaster University (since 1987) and Director of the Hamilton Regional Laboratory Medicine Program and Chief of the Departments of Laboratory Medicine at Hamilton Health Sciences and St. Joseph’s Healthcare (since 1998).

He received his medical degree and doctorate from the University of Glasgow. He was recruited to Dalhousie University, Nova Scotia in 1974 and to McMaster University in 1976. In 1981 he became a Fellow of the Royal College of Physicians of Canada and in 1984 a Founding Fellow of the Canadian Academy of Clinical Biochemistry.

Michael Chong

Assistant Director, CRLB-GMEL

Michael Chong is Assistant Director of the Clinical Research Laboratory and Biobank (CRLB) – Genetic and Molecular Epidemiology Laboratory (GMEL). He is also a Research Associate at McMaster University in the Department of Pathology and Molecular Medicine. To date, he has published approximately 40 articles related to stroke and cardiovascular disease genetics, mitochondrial genomics, biomarkers, and bioinformatics.

He completed his MSc in Medical Sciences at McMaster University (2012-2014) under the supervision of Guillaume Paré, where he studied the role of rare genetic variants as risk factors for early-onset stroke. From 2015-2017, he worked as a bioinformatician at GMEL and played key roles in the genetic analyses of several PHRI studies including INTERSTROKE and ORIGIN. From 2018-2021, he completed his PhD in Biochemistry at McMaster university, where he integrated genetics and biomarker data to uncover novel drug targets for stroke.

Tara Bryce

Operations Manager

Tara Bryce is the Operations Manager for the Clinical Research Laboratory and Biobank (CRLB) and Genetics and Molecular Epidemiology Laboratory (GMEL). A member of the CRLB since 2007, Tara has over 13 years’ experience as a laboratory professional, with expertise in biobanking and clinical research.

Tara holds an Honours Bachelor of Science from McMaster University, and is a Medical Laboratory Technologist registered with the College of Medical Laboratory Technologists of Ontario (CMLTO).

Reina Ditta

Academic & Research Dev. Manager

Reina Ditta is the Academic and Research Development Manager of the Genetics and Molecular Epidemiology Laboratory (GMEL) – Clinical Research Laboratory and Biobank (CRLB). Previously, she was the lab manager, GMEL, at PHRI.

Reina received her Honours Cell Biology from Western University, her Master’s in Forensic Science from King’s College London, and has more than 11 years of laboratory experience.

Matthew Lanktree

Investigator

Matthew Lanktree is a clinical scientist in adult nephrology genetics who cares for patients with chronic and end-stage kidney disease at St. Joseph’s Healthcare Hamilton and Hamilton Health Sciences. He is an Assistant Professor, Department of Medicine (division of nephrology) and Department of Health Research, Methods, Evidence and Impact, at McMaster University. His research areas of interest are: nephrology genetics; cardiovascular disease in patients with chronic kidney disease; dialysis; and polycystic kidney disease.

He obtained a combined MD and PhD at Western University with research in human genetics before residency in internal medicine and nephrology at McMaster University. He then completed a post-doctoral research fellowship in heritable kidney disease at the University of Toronto before returning to McMaster as faculty in 2019. He has published more than 60 articles in high-impact journals in genetics and medicine, and has set his goal to translate genetic studies into improved care of patients with kidney disease.

Marie Pigeyre

Investigator

Marie Pigeyre is an Investigator at PHRI, and Assistant Professor in the Division of Endocrinology, McMaster University. She has received peer-reviewed New Investigating Funding from Hamilton Health Sciences, and is supported by the Medicine Internal Career Award from McMaster University.

She completed her clinical and research post-doctoral fellowship in epidemiology, genetics and biomarkers at McMaster University in 2019, preceded by a PhD in Epidemiology and Genetics, medical degree, and endocrinology training at the University of Lille in France (2007).