ongoing

Up to 20% of patients undergoing major thoracic surgery develop perioperative atrial fibrillation (POAF), making it one of the most common serious complications in this patient population.

The objective of the COP-AF study is to determine whether the administration of colchicine reduces the occurrence of POAF and other inflammatory complications within 30 days after major thoracic surgery.

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Study Type

Interventional - Drug

Study Design

Multi-centre, blinded, randomized placebo-controlled trial

NO. of Countries

15

NO. of Sites

40

NO. of Participants

2800

Study Period

2018-2021

Sponsor

PHRI

Canadian Institutes of Health Research (CIHR)

Hamilton Health Sciences

McMaster University

Hamilton Academic Health Sciences Organization (HAHSO

PHRI Internal Award

McMaster AFP Award

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