Colchicine For Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF) was a multi-center, blinded, pilot randomized controlled pilot study of 100 patients.

The primary objectives were:

1) To determine the feasibility of recruiting patients undergoing thoracic surgery to an RCT of colchicine vs. placebo for the prevention of perioperative atrial fibrillation (AF).

2) To determine the resources required to achieve recruitment, pre-operative randomization, and to conduct a full scale trial; and

3) To assess the compliance with the trial protocol.

Secondary objectives were to determine the incidence of new onset perioperative AF or atrial flutter within the index hospitalization, death, myocardial injury after noncardiac surgery (MINS), stroke or transient ischemic attack (TIA), clinically important bradycardia, clinically important hypotension, life threatening bleeding, major bleeding, sepsis/infection, non infectious diarrhea, as well as on the duration of ICU, step-down and in-hospital stay.

Study Type

Interventional - Drug

Study Design

Blinded, multicenter pilot RCT

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NO. of Sites


NO. of Participants


Study Period




Physicians' Services Incorporated Foundation (PSI)

Canadian Institutes of Health Research (CIHR)

McMaster University

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