Interventional - Drug
Colchicine For Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF) was a multi-center, blinded, pilot randomized controlled pilot study of 100 patients.
The primary objectives were:
1) To determine the feasibility of recruiting patients undergoing thoracic surgery to an RCT of colchicine vs. placebo for the prevention of perioperative atrial fibrillation (AF).
2) To determine the resources required to achieve recruitment, pre-operative randomization, and to conduct a full scale trial; and
3) To assess the compliance with the trial protocol.
Secondary objectives were to determine the incidence of new onset perioperative AF or atrial flutter within the index hospitalization, death, myocardial injury after noncardiac surgery (MINS), stroke or transient ischemic attack (TIA), clinically important bradycardia, clinically important hypotension, life threatening bleeding, major bleeding, sepsis/infection, non infectious diarrhea, as well as on the duration of ICU, step-down and in-hospital stay.
Interventional - Drug
Blinded, multicenter pilot RCT
PJ Devereaux is Senior Scientific Lead, Perioperative and Surgery, PHRI, Professor and University Scholar in the Departments of Health Research Methods, Evidence, and Impact (HEI) and Medicine at McMaster University, and Director of the Division of Cardiology at McMaster.
The focus of his clinic research is vascular complications around the time of surgery, leading several large, international RCTs and observational studies addressing this issue. He has published more than 250 peer-reviewed papers and more than 50 book chapters and editorials. He is supported by a Tier 1 Canadian Research Chair in Perioperative Medicine, and holds the Yusuf Chair in Cardiology at McMaster University.
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
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