Landmark Research Studies

The objective of the VISION study was to collect international data regarding major adverse vascular events during non-cardiac surgery.

The increase in elderly patients undergoing surgery, the change in the invasiveness of some surgical interventions, and the limitations of previous research, contribute to uncertainty about the current incidence of major vascular events in patients undergoing noncardiac surgery.

Further, uncertainty exists regarding the optimal clinical risk estimation model for predicting major perioperative vascular events. There is promising but inconclusive evidence that troponin measurements after surgery may allow physicians to avoid missing MIs and predict mortality in the first year after surgery.

Primary endpoint:

Composite of vascular death, nonfatal myocardial infarction, nonfatal cardiac arrest, and nonfatal stroke.

Secondary endpoints:

All the individual components of the composite and each of:

  • Cardiac revascularization procedures
  • Congestive heart failure
  • New clinically important atrial fibrillation
  • Deep venous thrombosis
  • Pulmonary embolus
  • Re-hospitalization for vascular reasons,
  • Amputation
  • Bleeding
  • Pneumonia
  • Dialysis
  • Mew diagnosis of diabetes
  • Sepsis/infection.

Not adjudicated.

VISION MINS Results - Download PDF VISION Mortality Results - Download PDF
Study Type

Observational - Registry

Study Design

Prospective cohort study

NO. of Countries


NO. of Sites


NO. of Participants


Study Period

2007 - 2014


CLARITY McMaster University

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