Interventional - Procedure
A hip fracture causes bleeding, pain and immobility, and initiates inflammatory, hypercoagulable, catabolic and stress states in patients. Accelerated surgery may improve outcomes by reducing the duration of these states and immobility.
The objective of the HIP ATTACK-1 trial is to determine the effect of accelerated medical clearance and accelerated surgery compared to standard care on the 90-day risk of the following two co-primary outcomes: all-cause mortality and major perioperative complications.
Primary outcome measures:
1) All-cause mortality; and
2) composite of major perioperative complications:
i.e., mortality, nonfatal myocardial infarction, nonfatal venous thromboembolism, nonfatal pneumonia, nonfatal sepsis, nonfatal stroke, nonfatal life-threatening bleeding, and major bleeding) at 90 days after randomization.
Mohit Bhandari is Co-Principal Investigator of the HIP ATTACK-1 trial, along with PJ Devereaux.HIP ATTACK Slides - Download PDF
Interventional - Procedure
Multicentre, parallel group RCT
2014 - 2020
PJ Devereaux is Senior Scientific Lead, Perioperative and Surgery, PHRI, Professor and University Scholar in the Departments of Health Research Methods, Evidence, and Impact (HEI) and Medicine at McMaster University, and Director of the Division of Cardiology at McMaster.
The focus of his clinic research is vascular complications around the time of surgery, leading several large, international RCTs and observational studies addressing this issue. He has published more than 250 peer-reviewed papers and more than 50 book chapters and editorials. He is supported by a Tier 1 Canadian Research Chair in Perioperative Medicine, and holds the Yusuf Chair in Cardiology at McMaster University.
Flavia Kessler Borges is an investigator in the perioperative and surgery research group at PHRI, and internist, and an Assistant Professor, Department of Medicine (perioperative care; general internal medicine), McMaster University. Her research is focused on perioperative cardiac biomarkers, and perioperative strategies to improve clinical outcomes in patients undergoing noncardiac surgery.
She undertook her Masters in Health Sciences and her PhD in Cardiovascular Sciences in Brazil, and a research and clinical perioperative vascular fellowship under the direction of PJ Devereaux at McMaster. She holds an Early Career Research Award from McMaster.
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
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