Interventional - Procedure
The prevalence of gallstones in 10-20% among Canadians. About 10% of these patients develop Acute Cholecystitis (AC).
Surgery is the only definitive treatment for AC. Recent studies suggest that early surgery may be associated with shorter length of stay in hospital; less cost of care; and fewer complications. Controversy remains regarding the optimal timing of cholecystectomy surgery.
The FAST Pilot study aimed to inform the design of a large clinical trial that compared the outcomes of patients with AC who received accelerated surgery (i.e. as soon as possible with a goal of surgery within 6 hours of diagnosis) with those patients who received standard care.FAST Pilot Slides - Download PDF
Interventional - Procedure
Multicentre, parallel group RCT
2020 - 2022
PJ Devereaux is Senior Scientific Lead, Perioperative and Surgery, PHRI, Professor and University Scholar in the Departments of Health Research Methods, Evidence, and Impact (HEI) and Medicine at McMaster University, and Director of the Division of Cardiology at McMaster.
The focus of his clinic research is vascular complications around the time of surgery, leading several large, international RCTs and observational studies addressing this issue. He has published more than 250 peer-reviewed papers and more than 50 book chapters and editorials. He is supported by a Tier 1 Canadian Research Chair in Perioperative Medicine, and holds the Yusuf Chair in Cardiology at McMaster University.
Flavia Borges is a Scientist in the perioperative and surgery research group at PHRI, and internist, and an Assistant Professor, Department of Medicine (perioperative care; general internal medicine), McMaster University. Her research is focused on perioperative cardiac biomarkers, and perioperative strategies to improve clinical outcomes in patients undergoing noncardiac surgery.
She undertook her Masters in Health Sciences and her PhD in Cardiovascular Sciences in Brazil, and a research and clinical perioperative vascular fellowship under the direction of PJ Devereaux at McMaster. She holds an Early Career Research Award from McMaster.
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
Senior Research Coordinator
With over 14 years experience in health research coordination, Emily is passionate about building exceptional teams that make a positive impact on global health. She has an Honours Bachelor’s of Arts degree (University of Guelph), Master’s of Political Science degree (McMaster University) and a certificate in Project Management (University of Toronto).
Her research interests include tobacco control, public and patient involvement, long-term care, evaluation and knowledge translation. At PHRI, she supports the perioperative and surgery studies, B-Free, FARGO, FAST, PREVENT and STRATUS.
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