Early Versus Delayed Timing of Intervention in Patients with Acute Coronary Syndromes
To compare relative efficacy, safety, and cost effectiveness of a management strategy of coronary angiography and intervention performed within 24 hours of randomization versus delayed coronary angiography and intervention in patients after 36 hours with ACS.
Randomized, single blind (outcomes assessor), parallel group design, safety/efficacy study.
Adjudicated. Composite of death, myocardial (re-) infarction, or stroke. Secondary Points: Death/myocardial infarction (MI)/stroke/refractory ischemia/repeat intervention at discharge/30d/180d. Death/MI/stroke at discharge/30d/180d. Major bleeding at 30d. Each component of the primary outcome individually at discharge/30d/180d.
Craig Horsman, Barbara Jedrzejowski, Brandi Meeks