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Research

Photo for OASIS Registry

OASIS Registry

Official Title

OASIS (Organization to Assess Strategies for Ischemic Syndromes)

Status

Completed

Overview

To evaluate the variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. Significant differences between countries were observed. The study concluded that higher rates of invasive and revascularisation procedures were associated with lower rates of refractory angina or readmission for unstable angina, no apparent reduction in cardiovascular death or myocardial infarction, but with higher rates of stroke and suggested that randomised trials should assess the relative impact of conservative and more aggressive approaches to invasive cardiac procedures and revascularisations in patients with unstable angina.

Study Design

Observational study

Primary Endpoint

Data on clinical variables, procedures, and events were collected prospectively during the patient’s stay in hospital by means of standard forms. Data on transfers from one hospital to another for a procedure were also recorded. At 6 months, data were collected on all interim procedures, occurrence of myocardial infarction, readmission for unstable angina, and death. Events were not adjudicated.

Number of Patients

7987

Number of Sites

95

Number of Countries

6

Study Period

1996–1998

Principal Investigator

Salim Yusuf

Program Manager

Not Applicable

Research Coordinator

Lisa Cronin

Key Publications

  • Yusuf S, Flather M, Pogue J, Hunt D, Varigos J, Piegas L, Avezum A, Anderson J, Keltai M, Budaj A, Fox K, Ceremuzynski L. Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. OASIS (Organisation to Assess Strategies for Ischaemic Syndromes) Registry Investigators. Lancet. 1998;352(9127):507-14.