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Research

Photo for LAAOS III

LAAOS III

Official Title

Left Atrial Appendage Occlusion Study III

Status

Ongoing

Overview

To determine if removing the left atrial appendage can reduce stroke and other complications on top of usual therapy.

Study Design

Randomized, blinded, international multicentre trial

Primary Endpoint

The primary outcome is the first occurrence of stroke or systemic arterial embolism over the duration of follow-up.

The secondary outcomes over the duration of follow-up (unless otherwise specified) are:

1) Total mortality

2) Operative safety outcomes (chest tube output in the first post-operative 24 hours, rate of post-operative re-exploration for bleeding in the first 48 hours post-surgery and 30-day mortality)

3) Re-hospitalization for heart failure

4) Major bleed

5) Myocardial infarction

Number of Patients

4700

Number of Sites

100

Number of Countries

20

Study Period

2012–2020

Principal Investigator

Richard Whitlock, Stuart Connolly

Program Manager

Susan Chrolavicius, Shirley Pettit

Research Coordinator

Kate Brady