Left Atrial Appendage Occlusion Study III
To determine if removing the left atrial appendage can reduce stroke and other complications on top of usual therapy.
Randomized, blinded, international multicentre trial
The primary outcome is the first occurrence of stroke or systemic arterial embolism over the duration of follow-up.
The secondary outcomes over the duration of follow-up (unless otherwise specified) are:
1) Total mortality
2) Operative safety outcomes (chest tube output in the first post-operative 24 hours, rate of post-operative re-exploration for bleeding in the first 48 hours post-surgery and 30-day mortality)
3) Re-hospitalization for heart failure
4) Major bleed
5) Myocardial infarction
Richard Whitlock, Stuart Connolly
Susan Chrolavicius, Shirley Pettit