Age-related cognitive decline and dementia are huge public health problems that have touched most of us through afflicted family or friends. Vascular mechanisms are estimated to account for about one-third of cognitive decline in the elderly, and cognitive decline is the most frequent manifestation of cerebrovascular disease. There is emerging evidence that treatment of vascular disease and vascular risk factors can reduce cognitive and functional decline. PHRI has extensive experience in clinical trials aimed at treatment of vascular risk factors and prevention of vascular disease.
In the PHRI Brain Health Initiative, we will launch a series of innovative studies aimed at understanding and preserving brain health. These will include assessing global variations in dementia in a prospective study in 26 countries (the PURE study), elucidating the impact of environmental and lifestyle factors on dementia, and undertaking biomarker analyses to discover novel potential modifiable pathways that lead to cognitive decline and dementia.
Read the Minutes of the PHRI Brain Health Initiative Workshop held on January 9-10, 2019.