Atherosclerosis is a chronic lipid-driven inflammatory disease and the major cause of myocardial infarction, stroke, acute limb ischemia, and mortality. Peripheral artery disease (PAD) is one of its three major manifestations that affects over 230 million people worldwide.
With the ageing demographics and the increase in smoking and diabetes, the global burden of PAD is expected to rise substantially. The foundations of secondary prevention include lifestyle changes, risk factor modification, and antithrombotic therapy. Despite these therapies, patients with PAD have unacceptably high risk of vascular complications.
Additional strategies to reduce vascular risk are needed. Although atherosclerosis is fundamentally an inflammatory disease, existing therapies do not primarily target inflammation.
Colchicine, a low-cost anti-inflammatory drug, reduces vascular events in patients with coronary artery disease but it has not been tested in patients with PAD. Consequently, colchicine deserves further evaluation in patients with PAD, who are expected to derive an even greater benefit because of the extensive atherosclerosis.
To bridge this gap, the LEADER-PAD trial will determine if anti-inflammatory therapy with colchicine will reduce cardiovascular and limb events in patients with PAD.
Randomized, double-blind, placebo-controlled
2021 - 2023
HHS through PHRI
Noel Chan is an Assistant Professor in the Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, specializing in anticoagulant therapy and thrombosis medicine. His research seeks to improve our understanding of the triggers for thrombosis (including the role of inflammation) and the determinants of variable response to antithrombotic therapies to inform on novel strategies that have the potential to further reduce the burden of thrombosis.
Jessica Tyrwhitt has more than 10 years’ experience in coordinating and managing large, international clinical trials. She oversees interventional trials, registries, and observational research studies looking at primary and secondary prevention of cardiovascular disease in a variety of therapeutic areas, including cardiology, thrombosis, nephrology, cardio-oncology and diabetes.
She holds an Honours Bachelor of Science Degree & Business from the University of Waterloo.
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