Interventional - Drug
The AXIOMATIC SSP study is a global, phase 2, randomized, double-blind, placebo-controlled, dose-ranging Study of BMS-987177, an oral factor XIa inhibitor, for the prevention of new ischemic stroke or new silent brain infraction in patients receiving aspirin and clopidogrel following acute non-hemorrhagic stroke or transient ischemia attack (TIA).
The purpose of this clinical study is to determine whether the addition of an oral Factor XIa Inhibitor to aspirin and clopidogrel is more effective than standard therapy in secondary stroke prevention.
More about this study at: ClinicalTrials.gov.
Interventional - Drug
Double-blind placebo-controlled dose-ranging RCT
2019 - 2021
Bristol Myers Squibb, Janssen
Mike Sharma is a stroke neurologist at Hamilton Health Sciences, Associate Professor – Division of Neurology, Department of Medicine, McMaster University, and a scientist in the stroke program at PHRI. He has an interest in clinical trials in secondary stroke prevention, covert stroke, and economics of stroke care.
Mike is Chair of the Canadian Stroke Consortium, and was the Deputy Director for Clinical Affairs and Health Policy of the Canadian Stroke Network, one of Canada’s Networks of Centers of Excellence. He has published more than 31 papers in peer review journals. After completing his fellowship at McGill University and the University of Ottawa, Mike relocated to McMaster University in 2013.
Kanjana (Sashi) Perera is an Investigator in the Brain Health research program at PHRI, Assistant Professor, Medicine (neurology), McMaster University, and a stroke neurologist at Hamilton Health Sciences. Her main research focus is on secondary stroke prevention, cryptogenic stroke, and uncommon causes of stroke and the optimization of clinical care in this patient population.
She has served as Principal Investigator and Co-Investigator for Phase II and III clinical trials, and is on the adjudication committees for international multicenter stroke/cardiovascular trials. She has won research awards, and her work has been published in high-impact medical journals. She obtained her medical degree from Sri Lanka with Honors for academic excellence. She completed her training in Neurology at the University of Western Ontario in 2013 and subsequently pursued a fellowship in Stroke/Vascular Neurology at McMaster University.
Associate Program Manager
Dipika Desai oversees many epidemiologic studies, including the South Asian birth cohort, START, the South Asian Heart Risk Assessment (SAHARA), and the Canadian Alliance for Healthy Hearts and Minds (CAHHM), as well as management assistance and oversight in the utilization of samples from a number of other studies.
She has a Bachelor’s degree in Food and Nutrition from the M S University in Baroda, India, and a Master’s degree in Human Nutrition from the University of British Columbia.
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