completed

We wanted to undertake a large international factorial RCT to establish the effects of rosuvastatin versus placebo and tranexamic acid versus placebo in patients undergoing noncardiac surgery (i.e. the POISE-3 Trial).

Prior to undertaking a large international trial, we first need to undertake a pilot to establish the feasibility of such an RCT.

Primary endpoints:

  • To determine the feasibility and the resource requirements of a trial of rosuvastatin versus placebo and tranexamic acid (TXA) versus placebo
  • To determine the feasibility of administering perioperative rosuvastatin and TXA in patients with, or at risk of, atherosclerotic disease who are undergoing noncardiac surgery.
Study Type

Interventional - Drug

Study Design

Multicentre, blinded, placebo controlled randomized

NO. of Countries

1

NO. of Sites

2

NO. of Participants

100

Study Period

2015

Sponsor

PHRI

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