Interventional - Drug
POISE-3 is an international multi-centre randomized clinical trial to assess the impact of tranexamic acid (TXA) versus placebo, and to assess the impact of managing hypotension versus standard of care in patients undergoing non-cardiac surgery who are at risk of a perioperative cardiovascular event.
The primary objective of POISE-3 is to determine the incidence of a composite of myocardial infarction, stroke and pulmonary embolism. Patients will be followed for one year.POISE-3 Presentation - Download PDF
Interventional - Drug
Multi-centre, blinded, randomized controlled trial
2018 - 2021
PJ Devereaux is Senior Scientific Lead, Perioperative and Surgery, PHRI, Professor and University Scholar in the Departments of Health Research Methods, Evidence, and Impact (HEI) and Medicine at McMaster University, and Director of the Division of Cardiology at McMaster.
The focus of his clinic research is vascular complications around the time of surgery, leading several large, international RCTs and observational studies addressing this issue. He has published more than 250 peer-reviewed papers and more than 50 book chapters and editorials. He is supported by a Tier 1 Canadian Research Chair in Perioperative Medicine, and holds the Yusuf Chair in Cardiology at McMaster University.
Associate Program Manager
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
Senior Research Coordinator
Ingrid Copland has been working in research for McMaster University since 1991. She has been at PHRI for 23 years where she has coordinated large, international, industry and investigator initiated trials. Since 2014 she has been with the perioperative and surgery department coordinating observational, drug and device trials.
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