POISE-3 is an international multi-centre randomized clinical trial to assess the impact of tranexamic acid (TXA) versus placebo, and to assess the impact of managing hypotension versus standard of care in patients undergoing non-cardiac surgery who are at risk of a perioperative cardiovascular event.

The primary objective of POISE-3 is to determine the incidence of a composite of myocardial infarction, stroke and pulmonary embolism. Patients will be followed for one year.

POISE-3 Presentation - Download PDF
Study Type

Interventional - Drug

Study Design

Multi-centre, blinded, randomized controlled trial

NO. of Countries


NO. of Sites

300 target

NO. of Participants

10000 target

Study Period

2018 - 2021



CIHR Foundation Grant

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