A randomized double-blind placebo-controlled trial for the evaluation of a polypill (with and without aspirin) and vitamin D supplementation in a primary prevention setting to reduce cardiovascular disease (CVD) outcomes – The International Polycap Study 3
To evaluate a polypill (with and without aspirin) and vitamin D supplementation in a primary prevention setting to reduce cardiovascular disease (CVD) outcomes
Randomized, double-blind, 2x2x2 factorial, placebo controlled trial determining the effect of double strength Polycap™ , aspirin, and vitamin D compared to their respective placebos.
Number of Patients
Number of Sites
Salim Yusuf, Koon Teo
- Lonn E, Bosch J, Teo KK, et al. The Polypill in the Prevention of Cardiovascular Diseases: Key Concepts, Current Status, Challenges, and Future Directions. Circulation. 2010; 122: 2078-2088.
- Smith R, McCready T, Yusuf S. Combination therapy to prevent cardiovascular disease: slow progress. JAMA. Apr 17 2013;309(15):1595-1596.
- Writing Group on the Summit on Combination Therapy for CVD (Yusuf S, Ataran A, Bosch J, Joseph P, Lonn E, McCready T, Mente A, Nieuwlaat R, Pais P, Rodgers A, Schwalm J-D, Smith R, Teo K, Xavier D). Combination Pharmacotherapy to Prevent CVD: Present Status and Challenges. Eur Heart J. 2013 (Nov) doi:10.1093/Eurheartj/eht407.