The PeriOperative ISchemic Evaluation-3 (POISE-3) pilot Trial
We want to undertake a large international factorial RCT to establish the effects of rosuvastatin versus placebo and tranexamic acid versus placebo in patients undergoing noncardiac surgery (i.e. the POISE-3 Trial). Prior to undertaking a large international trial, we first need to undertake a pilot to establish the feasibility of such an RCT.
Multicentre, blinded, randomized placebo controlled trial of rosuvastatin and tranexamic acid (TXA)
To determine the feasibility and the resource requirements of a trial of rosuvastatin versus placebo and tranexamic acid versus placebo; and to determine the feasibility of administering perioperative rosuvastatin and TXA in patients with, or at risk of, atherosclerotic disease who are undergoing noncardiac surgery.