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Research

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FAMILY

Official Title

Family Atherosclerosis Monitoring In early life (FAMILY)

Status

Ongoing

Overview

To measure the environmental, metabolic and genetic factors that contribute to the development of excess adiposity and obesity related diseases that can have beginnings from the time of pregnancy to early childhood. The results of the FAMILY Cohort study will lead to a better understanding of the role of our genes and their interaction with the fetal/maternal environment in the development of adiposity, pre-diabetes and risk factors for heart disease in early childhood, school age, adolescence and young adulthood. With this knowledge, we can then develop recommendations to help women to have healthier pregnancies, and for better nutrition and lifestyle practices for growing children and young adults.

Study Design

Prospective Birth Cohort

Primary Endpoint

To collect information on nutrition, meal patterns, physical activity, growth, health, risk behaviours, socio-economic status, feeling of wellbeing and blood profiles, including analysis of genetic markers up to 10 years of age. All of this information is analyzed so that we can determine how each of these factors influence development of body fat during childhood and risk of obesity-associated markers of disease at 3, 5 and 10 years of age. We will also assess the heart health at the 10 year visit by performing a carotid ultrasound testing on the mother and the child.

Number of Patients

1000

Number of Sites

3

Number of Countries

1

Study Period

2002–TBA

Principal Investigator

Koon Teo

Program Manager

Sumathy Rangarajan

Research Coordinator

Nora Abdalla

Key Publications

  • Morrison KM, Atkinson SA, Teo KK. Fetal Origins of Coronary Artery Disease in Evidence Based Cardiology, 3rd edition, Ed. S Yusuf, J Cairns, J Camm, E Fallen, B Gersh, BMJ Books, Blackwell Publishing, 2009 In press
  • Morrison KM, Atkinson SA, Yusuf S, Bourgeois J, McDonald S, McQueen MJ, Persadie R, Hunter B, Pogue J, Teo KK, FAMILY investigators. The Family Atheroscleroisis Monitoring in early life (FAMILY) Study: Rationale, design, and baseline data of a study examining the early determinants of atherosclerosis. Am Heart J 2009, In press.
  • Morrison KM, et al. Cardiovascular risk factors and non-invasive assessment of subclinical atherosclerosis in youth. Atherosclerosis (2009), doi: 10.1016/j.atherosclerosis.2009.07.034.