Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery (DEPOSITION): Pilot Study
This pilot study aims to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TA) versus the usual intravenous TA in patients undergoing cardiac surgery at the Hamilton General Hospital. This pilot study will assess the feasibility to perform a large randomized international trial exploring this objective.
Randomized, double-blinded single-centre
We hypothesize that topical intra-pericardial (i.p.) application of Tranexamic Acid (TA) vs. intravenous (i.v.) will reduce postoperative bleeding in patients who have undergone cardiac surgery using cardiopulmonary bypass (CPB) and decrease or eliminate the risk of seizures.