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Photo for DEPOSITION Pilot

DEPOSITION Pilot

Official Title

Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery (DEPOSITION): Pilot Study

Status

Completed

Overview

This pilot study aims to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TA) versus the usual intravenous TA in patients undergoing cardiac surgery at the Hamilton General Hospital. This pilot study will assess the feasibility to perform a large randomized international trial exploring this objective.

Study Design

Randomized, double-blinded single-centre

Primary Endpoint

We hypothesize that topical intra-pericardial (i.p.) application of Tranexamic Acid (TA) vs. intravenous (i.v.) will reduce postoperative bleeding in patients who have undergone cardiac surgery using cardiopulmonary bypass (CPB) and decrease or eliminate the risk of seizures.

Number of Patients

100

Number of Sites

1

Number of Countries

1

Study Period

2017-2018

Principal Investigator

Andre Lamy

Program Manager

Shirley Pettit

Research Coordinator

Ingrid Copland

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