Inteventional - Drug
The primary object of the DEPOSITION study is to determine in patients undergoing on-pump cardiac surgery, if topical tranexamic acid (intra-pericardial) is superior to the usual intravenous tranexamic acid administration for reducing the risk of in-hospital red blood cell transfusion or seizure. We are proposing a multi-centre double-blinded randomized control trial including 3800 cardiac surgery patients to compare the effect of IV TxA with topical TxA on the proportion of patients requiring RBC transfusion.
We are starting with 500 participants at the Hamilton General Hospital with the PHRI internal funding grant. We successfully completed the DEPOSITION pilot study which included 107 cardiac surgery patients and proved feasibility of our proposed protocol. Subjects will be randomized in a 1:1 ratio to topical TxA (IV placebo + topical TxA) or intravenous TxA (IV TxA + topical placebo). The surgeons, anesthetists, along with research and clinical teams are blinded to the allocation. Patients will be followed in hospital until discharge or 10 days (whichever comes first).
Our vision is to produce strong evidence to support practice change in cardiac surgery toward the use of topical TxA.Download Presentation PDF
Inteventional - Drug
Multi-centre, double-dummy, randomized controlled trial
Andre Lamy is a cardiac surgeon practicing at the Hamilton Health Sciences since 1996, and Professor in the Department of Surgery, McMaster University. He led the Canadian Institute of Health Research funded CORONARY trial, which evaluated off-pump CABG surgery versus on-pump CABG surgery in 4752 patients. The results were published in the New England Journal of Medicine in 2012 and 2013.
Associate Program Manager
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
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