The UNIVERSAL study is a randomized, controlled trial to determine whether the use of ultrasound guidance for vascular access during coronary angiography or percutaneous coronary intervention (PCI) will reduce the rates of major vascular complications.

Patients who will undergo a coronary angiography or PCI using femoral access will be allocated to either:

  1. Femoral access using fluoroscopic and ultrasound guidance, or
  2. Femoral access using fluoroscopic guidance alone.

Primary endpoints:

  • Incidence of major vascular complications [ Time Frame: up to 30 days post-procedure ]
  • Femoral artery pseudonaneurysm
  • Arteriovenous fistula
  • Retroperitoneal bleed
  • Major bleed based on BARC III criteria
  • Hematoma with more than 5 cm of diameter.
UNIVERSAL - TCT 2022 (download PDF)
Study Type

Interventional - Procedure

Study Design

Parallel assignment, double masking RCT

NO. of Countries


NO. of Sites


NO. of Participants


Study Period

2018 - 2022



Hamilton Health Sciences

Innovation Fund, Division of Cardiology, Department of Medicine, McMaster University (2018)

TCT 2023: Sanjit Jolly on UNIVERSAL trial: Routine ultrasonography guidance for femoral vascular access for cardiac procedures

Sanjit Jolly and Marc-Andre d'Entremont at CRT 2023

CRT 2023: Sanjit Jolly on ultrasound-guided femoral access in patients with vascular closure devices: a prespecified analysis of UNIVERSAL

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