ongoing

The TOF-LIFE study is a large, multicentre, international, prospective cohort study to determine the association between baseline cardiac morphology, surgical repair technique (VSD closure and managing the RVOT), and RV physiology and morphology at two years.

Primary outcomes will be obtained from echocardiogram studies: indexed RV diastolic dimension, RV/LV diastolic diameter ratio, RV function and LV function, residual RVOT obstruction, and pulmonary insufficiency.

TOF-LIFE Slides - Download PDF
Study Type

Observational

Study Design

International multi-centre inception cohort study

NO. of Countries

15

NO. of Sites

25

NO. of Participants

3000

Study Period

2015-2021

Sponsor

PHRI

The Hospital for Sick Children, Toronto

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