The objective of the Remote IMPACT study was:

  • To determine the effect of remote ischemic preconditioning (RIPC) on surrogate endpoints of cardiac and kidney injury, and;
  • To determine what combination of limbs used and number of cycles is most effective.

Primary endpoints:

1) recruitment rate per centre
2) follow-up completeness at 30 days and 6 months after surgery

Secondary endpoints:

1) Peak change in CK-MB in the first 24 hours after surgery
2) Peak change in serum creatinine in the first 4 days after surgery
3) Number of days in the intensive care unit and in hospital after surgery
4) Incidence of death from any cause at 30 days after surgery
5) Incidence of new dialysis required within 30 days after surgery
6) Incidence of documented myocardial infarction at 30 days after surgery
7) Incidence of documented stroke at 30 days after surgery

Study Type

Interventional - Procedure

Study Design

Randomized, double-blind, multicentre, controlled trial of 2 parallel groups

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NO. of Sites


NO. of Participants


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