ongoing

The PRINCE trial will evaluate the effectiveness and safety of a surgical intervention called “left posterior pericardiotomy” in preventing POAF and improving post-discharge clinical outcomes in a broad spectrum of heart surgery patients.

PRINCE has two objectives:

  • To evaluate whether left posterior pericardiotomy reduces the incidence of in-hospital postoperative atrial fibrillation (POAF) in the first five postoperative days.
  • To evaluate whether left posterior pericardiotomy decreases the risk of the hierarchical composite of all-cause death, stroke, systemic arterial embolism, unplanned hospital visit/readmission for cardiac reasons, or atrial fibrillation after 30 days over the duration of follow-up.

The clinical outcomes that occur will then be compared between the two groups to assess whether patients who undergo left posterior pericardiotomy have better clinical outcomes and quality of life. The study will enroll 1,400 patients globally. Participants will be followed for an average of five years after their heart surgery to determine any complications they may have.

About PRINCE
Study Type

Surgical

Study Design

international, multicentre, randomized controlled trial

NO. of Countries

9

NO. of Sites

22

NO. of Participants

1400

Study Period

2024-2031

Sponsor

PHRI

Weill Cornell Medicine

Medical University of Vienna

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