Study Type
Phase IV
PICS (Prevention of Infections in Cardiac Surgery: a cluster randomized factorial cross-over trial is a 32,000-patient multicentre factorial, cluster crossover study. Centers will be randomized to one of eight orders of the four study arms: a) cefazolin short-term, b) cefazolin long-term, c) cefazolin plus vancomycin short-term and d) cefazolin plus vancomycin long-term. Each study arm will be implemented for 6 months, and the strategy will become standard of care for all patients undergoing cardiac surgery during that time period. The primary goal is to determine the effects of dual antibiotic prophylaxis and of different durations of post-operative antibiotic prophylaxis on sternal surgical site infections in patients undergoing cardiac surgery.
DownloadPhase IV
Multi-center, factorial, cluster crossover study
1
20
32000
2025-2028
PHRI
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