ongoing

PICS (Prevention of Infections in Cardiac Surgery: a cluster randomized factorial cross-over trial is a 32,000-patient multicentre factorial, cluster crossover study. Centers will be randomized to one of eight orders of the four study arms: a) cefazolin short-term, b) cefazolin long-term, c) cefazolin plus vancomycin short-term and d) cefazolin plus vancomycin long-term. Each study arm will be implemented for 6 months, and the strategy will become standard of care for all patients undergoing cardiac surgery during that time period. The primary goal is to determine the effects of dual antibiotic prophylaxis and of different durations of post-operative antibiotic prophylaxis on sternal surgical site infections in patients undergoing cardiac surgery.

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Study Type

Phase IV

Study Design

Multi-center, factorial, cluster crossover study

NO. of Countries

1

NO. of Sites

20

NO. of Participants

32000

Study Period

2025-2028

Sponsor

PHRI

Canadian Institutes of Health Research

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