Interventional - Drug
The objective of the MANAGE trial was to assess the impact of dabigatran (a direct thrombin inhibitor) in patients suffering myocardial injury after noncardiac surgery (MINS).
In addition, a partial 2×2 factorial design was used to randomize patients not already on a proton pump inhibitor to either omeprazole or matching placebo.
The trial intended to determine the effect of dabigatran 110 mg versus matching placebo on the risk of major vascular complications, and the effect of omeprazole 20 mg versus matching placebo on the risk of major upper gastrointestinal complications in patients who have suffered MINS. Patients were followed-up for an average of one year post-randomization.
Major upper gastrointestinal complication (composite of overt gastroduodenal bleeding, overt upper gastrointestinal bleeding of unknown origin, or upper gastrointestinal perforation)MANAGE Main Results 2018 - Download PDF
Interventional - Drug
Multicentre, international, 2x2 partial factorial RCT
PJ Devereaux is Senior Scientific Lead, Perioperative and Surgery, PHRI, Professor and University Scholar in the Departments of Health Research Methods, Evidence, and Impact (HEI) and Medicine at McMaster University, and Director of the Division of Cardiology at McMaster.
The focus of his clinic research is vascular complications around the time of surgery, leading several large, international RCTs and observational studies addressing this issue. He has published more than 250 peer-reviewed papers and more than 50 book chapters and editorials. He is supported by a Tier 1 Canadian Research Chair in Perioperative Medicine, and holds the Yusuf Chair in Cardiology at McMaster University.
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
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