Study Type
Interventional - Procedure
The objective of the LAAOS III study is to determine if removing the left atrial appendage can reduce stroke and other complications on top of usual therapy.
Primary outcome:
The first occurrence of ischemic stroke* or transient ischemic attack with positive neuroimaging or systemic arterial embolism over the duration of follow-up.
Secondary outcomes over the duration of follow-up (unless otherwise specified) are:
1) All cause stroke or transient ischemic attack with positive neuroimaging or systemic arterial embolism.
2) Composite of ischemic stroke* or transient ischemic attack with positive neuroimaging or systemic arterial embolism or death.
3) Ischemic stroke *or transient ischemic attack with positive neuroimaging or systemic arterial embolism occurring more than 30 days after surgery.
4) All cause death.
Safety outcomes:
1) Hospitalization for heart failure.
2) Operative safety outcomes.
a. Chest tube output in the first post-operative 24 hours.
b. Re-operation for bleeding within the first 48 hours post-surgery.
c. 30-day mortality
3) Major bleed.
4) Myocardial infarction
* Ischemic stroke is defined as any stroke that is not documented as primary hemorrhagic.
All components of composite outcomes will also be reported individually.
LAAOS III Slides - Download PDFInterventional - Procedure
Randomized, blinded, multicenter
32
120
4811
2012 - 2021
PHRI
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