ongoing

The objective of the LAAOS III study is to determine if removing the left atrial appendage can reduce stroke and other complications on top of usual therapy.

Primary outcome:

The first occurrence of ischemic stroke* or transient ischemic attack with positive neuroimaging or systemic arterial embolism over the duration of follow-up.

Secondary outcomes over the duration of follow-up (unless otherwise specified) are:

1) All cause stroke or transient ischemic attack with positive neuroimaging or systemic arterial embolism.

2) Composite of ischemic stroke* or transient ischemic attack with positive neuroimaging or systemic arterial embolism or death.

3) Ischemic stroke *or transient ischemic attack with positive neuroimaging or systemic arterial embolism occurring more than 30 days after surgery.

4) All cause death.

Safety outcomes:

1) Hospitalization for heart failure.

2) Operative safety outcomes.

a. Chest tube output in the first post-operative 24 hours.

b. Re-operation for bleeding within the first 48 hours post-surgery.

c. 30-day mortality

3) Major bleed.

4) Myocardial infarction

* Ischemic stroke is defined as any stroke that is not documented as primary hemorrhagic.

All components of composite outcomes will also be reported individually.

Download Presentation PDF
Study Type

Interventional - Procedure

Study Design

Randomized, blinded, multicenter

NO. of Countries

32

NO. of Sites

120

NO. of Participants

4811

Study Period

2012 - 2021

Sponsor

PHRI

Hamilton Health Sciences

Canadian Institutes of Health Research (CIHR)

PHRI

McMaster Surgical Associates (MSA)

Heart & Stroke Foundation

Canadian Stroke Prevention Intervention Network (C-SPIN)

CANNeCTIN 

Back To Top