Interventional - Drug
The DANCE Pilot trial will compare the safety of direct oral anticoagulants (DOAC) versus warfarin in the early period (30 days) after cardiac surgery in patients with an indication for oral anticoagulation.
The objective of this trial is to determine the feasibility of conducting a larger trial.
The SUNDANCE trial – which is a sub-study of the DANCE trial – focuses on subclinical valve thrombosis in patients with bioprosthetic aortic valve replacement.DANCE and SUNDANCE substudy - Download PDF
Interventional - Drug
Multi-centre, open randomized controlled trial
2021 - 2023
Richard Whitlock is Associate Chair, Research, and a Professor at the Department of Surgery, McMaster University. He was awarded the inaugural Canada Research Chair in Cardiovascular Surgery in 2020.
As well as being a PHRI Scientist, Richard is a cardiac surgeon and intensive care physician at Hamilton Health Sciences. His clinical focus is on aortic valve intervention and aortic surgery. He is a lead investigator for the CIHR funded studies SIRS, LAAOS III, and TRICS III, which have established a network of more than 120 centres to address important questions in his field.
He has published more than 90 articles in referred journals. Medically qualified at the University of Toronto, Richard received his specialist training in cardiac surgery and critical care medicine at McMaster University. In 2012, he received his PhD in clinical epidemiology.
Emilie Belley-Côté is an Assistant Professor in the Department of Medicine at McMaster University; she practices critical care cardiology in the cardiovascular intensive care unit and coronary care unit at the Hamilton General Hospital. Her research interests include perioperative cardiac surgery care, knowledge synthesis and guideline development. At this stage in her career, she has more than 120 publications, including articles in NEJM, Lancet, JAMA, as well as first-tier critical care journals.
She obtained her MD from Université de Sherbrooke in 2006. After internal medicine and cardiology training, as well as an MSc in Clinical Sciences, she completed a critical care fellowship at McMaster. In 2019, she completed a PhD in Health Research Methodology at McMaster University.
Rachel Eikelboom is a cardiac surgery resident and PhD candidate in the Health Research Methodology program under the supervision of PHRI Scientist Richard Whitlock and PHRI Investigator Emilie Belley-Cote.
Her research interests are in antithrombotic therapy after bioprosthetic valve replacement. Rachel is a co-investigator of the SUNDANCE trial, a sub-study of the DANCE trial, which focuses on subclinical valve thrombosis in patients with bioprosthetic aortic valve replacement.
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
Kate Brady has worked in clinical research since 2008 and joined PHRI in 2010. She has experience in coordinating large international clinical trials and observational studies with a focus on cardiac surgery. She has an Honour’s Bachelor Degree in Science with an Honours Specialization in Genetics from Western University and a post-graduate certificate in Clinical Research from Humber College.
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