completed

The objective of the CORONARY study was to compare the risks and benefits of of Off-Pump Coronary artery bypass surgery (CABG) to On-Pump CABG, to determine if one is better than the other. The study was also conducted to see the rate of recruitment with expertise-based randomization across different hospital settings.

The study looked at which of the two techniques reduce major risks associated with CABG.

Primary endpoint:

The occurrence of the composite of total mortality, stroke, nonfatal MI, or new renal failure at 30 days post CABG surgery.

The occurrence of the composite of total mortality, stroke, nonfatal MI, new renal failure, or repeat coronary revascularization (i.e. coronary artery bypass surgery or percutaneous coronary intervention) over five years after randomization.

Secondary endpoint:

The assessment of total costs and resources consumption at 30 days after CABG surgery.

The assessment of total costs and resources consumption at 5 years after CABG surgery. All endpoints are adjudicated.

Study Type

Interventional - Procedure

Study Design

Randomized, treatment, open label, active control, parallel group design.

NO. of Countries

19

NO. of Sites

79

NO. of Participants

4752

Study Period

2006 - 2016

Sponsor

PHRI

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