Study Type
Pilot
BRACKETS (Bleeding Reduction in Acute and Chronic KidnEy patienTs having Surgery) is a 100-patient multicentre randomized controlled pilot trial. This trial compares preoperative prophylactic intravenous TXA versus placebo, and using a partial factorial design, preoperative prophylactic intravenous desmopressin versus placebo in people with advanced kidney disease having major noncardiac surgery. This pilot trial will determine the feasibility of a large international randomized trial to evaluate the efficacy and safety of TXA and desmopressin in patients with advanced kidney disease having major noncardiac surgery. The pharmacokinetic substudy will provide pharmacokinetic data to inform dose selection.
About BRACKETSPilot
Multicentre prospective randomized controlled trial, partial factorial design
1
10
100
2025-2027
PHRI
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