ongoing

BRACKETS (Bleeding Reduction in Acute and Chronic KidnEy patienTs having Surgery) is a 100-patient multicentre randomized controlled pilot trial. This trial compares preoperative prophylactic intravenous TXA versus placebo, and using a partial factorial design, preoperative prophylactic intravenous desmopressin versus placebo in people with advanced kidney disease having major noncardiac surgery. This pilot trial will determine the feasibility of a large international randomized trial to evaluate the efficacy and safety of TXA and desmopressin in patients with advanced kidney disease having major noncardiac surgery. The pharmacokinetic substudy will provide pharmacokinetic data to inform dose selection.

About BRACKETS
Study Type

Pilot

Study Design

Multicentre prospective randomized controlled trial, partial factorial design

NO. of Countries

1

NO. of Sites

10

NO. of Participants

100

Study Period

2025-2027

Sponsor

PHRI

London Health Sciences

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