Study Type
Pilot
BRACKETS (Bleeding Reduction in Acute and Chronic KidnEy patienTs having Surgery) is a 100-patient multicentre randomized controlled pilot trial. This trial compares preoperative prophylactic intravenous TXA versus placebo, and using a partial factorial design, preoperative prophylactic intravenous desmopressin versus placebo in people with severe kidney disease having major noncardiac surgery. This pilot trial will inform the feasibility and design of a large international trial to evaluate the efficacy and safety of TXA and desmopressin in patients with severe kidney disease undergoing noncardiac surgery, provide preliminary data regarding the efficacy and safety of TXA and desmopressin in people with severe kidney disease having noncardiac surgery, and provide pharmacokinetic data to inform dose selection.
About BRACKETSPilot
Multicentre prospective randomized controlled trial, partial factorial design
1
10
100
2025-2026
PHRI
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