Interventional - Drug
B-FREE is a pragmatic, multicentre, cluster crossover trial to evaluate whether a policy limiting the use of intra-operative benzodiazepine cardiac anesthesia reduces post-operative delirium in the intensive care unit (ICU) when compared with a policy of ad libitum administration.
The knowledge generated by this study will provide the basis for cardiac anesthesia practice guidelines.B-FREE Slides - Download PDF
Interventional - Drug
Pragmatic, multicentre, cluster crossover trial
2019 - 2022
Stuart Connolly is a Professor of Medicine at McMaster University and a cardiac electrophysiologist at Hamilton Health Sciences. He became a faculty member at McMaster University in 1983 and was awarded a full professorship in 1994. He was also appointed as the inaugural holder of the Salim Yusuf Chair in Cardiology at McMaster University.
He has published more than 270 scientific articles in the field, and is currently a member of the editorial boards for a number of prominent cardiology journals, including Heart, the American Heart Journal and the Journal of Pacing and Electrophysiology. His main research interests are focused on the evaluation of treatments for heart rhythm disorders. His academic career has been largely devoted to the design and execution of controlled clinical trials in this area.
He holds a Masters degree from Fordham University, New York, and an MD from McGill University in Montreal. He received his specialist training in cardiology at the University of Toronto and at Stanford University.
Jessica Spence is a cardiac anesthesiologist and intensivist who completed a research fellowship at PHRI and a PhD in Clinical Epidemiology under the supervision of PJ Devereaux.
She is an Assistant Professor at McMaster University and the Principal Investigator of the B-Free Cluster Crossover Trial. Her research program focuses on the perioperative outcomes of cardiac surgery.
Tara McCready, PhD, oversees a variety of collaborative programs at PHRI, and serves as Project Manager for PHRI research studies and registries.
She was recruited to PHRI as a Program Director for the Canadian Network and Centre for Trials Internationally (CANNeCTIN), a national network funded by the CIHR/CFI Clinical Research Initiative program to improve the prevention and treatment of cardiac and vascular diseases and diabetes.
Previously the Executive Director of the Canadian Maternal, Infant, Child and Youth Research Network, Tara holds a PhD in Biochemistry and a MBA in Technology Commercialization from the University of Alberta.
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