Atrial fibrillation (AF) often occurs transiently in the setting of an acute stressor (e.g. medical illness or surgery). Uncertainly exists as to whether AF Occurring Transiently with Stress (AFOTS) is secondary to a reversible precipitant and is benign, or is a first presentation of paroxysmal AF and associated with a risk of stroke.
AFOTS is a common occurrence (up to 15-40% in intensive care), but there is a lack of evidence to guide its management and guidelines have called for further research in this area.
The objective of the AFOTS Recurrence study is to use a sensitive strategy to determine the rate of recurrent AF among patients who experienced AFOTS following non-cardiac surgery or medical illness, compared to matched controls.AFOTS-Recurrence Information - Download PDF
Case control cohort
Jeff Healey is a Senior Scientist in the Arrhythmia and Heart Failure research program at PHRI, an Associate Professor, Medicine, McMaster University, and Director of Arrhythmia Services at Hamilton Health Sciences. His research involves conducting RCTs and large registries in the fields of atrial fibrillation and cardiac devices. He was the lead author of the SIMPLE trial, published in the Lancet in 2015, which demonstrated that implantable defibrillators could be safely inserted without performing intra-operative defibrillation testing.
He was the lead author of the ASSERT trial, published in New England Journal of Medicine in 2012, demonstrating the increased stroke risk associated with sub-clinical atrial fibrillation detected by pacemakers. Thomson-Reuters recognized ASSERT as the 38th most-cited scientific publication in 2012 (#16 in Medicine).
He was principal investigator and chair of the Canadian Stroke Prevention Intervention Network (CSPIN), a ten-year network grant funded by the Canadian Institutes of Health Research, The Heart and Stroke Foundation of Canada and Industry. He is the past co-chair of the Canadian Cardiovascular Society’s Atrial Fibrillation Guidelines Committee. Jeff has published more than 185 manuscripts.
William McIntyre is an Assistant Professor (cardiology), Department of Medicine, McMaster University, a cardiologist at Hamilton Health Sciences, and an Investigator in the Arrhythmia and Heart Failure research program at PHRI. His research interests include atrial fibrillation – including screening, detection and cardioversion, cardiac devices and methods in randomized clinical trials.
He holds fellowship awards from CIHR and the Canadian Stroke Prevention Intervention Network (C-SPIN). He holds research grants from the Canadian Cardiovascular Society (CCS) Atrial Fibrillation Awards Program and the Heart and Stroke Foundation of Canada. William has published more than 50 peer-reviewed articles, and was the 2018 Recipient of the CCS Trainee Excellence in Education Award. He completed Medical School and Internal Medicine Residency at Queen’s University, and his adult cardiology residency at the University of Manitoba.
Study Team Specialist
Heather Beresh has worked at PHRI since May 2002, largely devoted to managing global, multi-centre clinical trials of antithrombotic therapies in patients with atrial fibrillation (AF). She started as research coordinator for the ACTIVE study evaluating dual antiplatelet therapy and angiotensin receptor blockers in patients with AF, then continued with oversight of the AVERROES open label extension trial evaluating a novel oral anticoagulant in the same population, and ARTESiA evaluating anticoagulant therapy in patients with subclinical AF.
After years as Associate Program Manager for the Heart Failure and Arrhythmia Program, managing networks such as C-SPIN, and on the ACT COVI-19 research program, Heather was made Study Team Specialist in 2021, to provide regulatory, country and site management expertise to the studies in the Global Health research team. She has as a Master’s degree in Medical Sciences from McMaster University.
Senior Research Coordinator
Alex Grinvalds has more than 15 years experience in clinical research, of which 13 have been at PHRI. He has worked on randomized studies, device trials and numerous registries. Currently, Alex is working on studies involving patients with heart failure and arrhythmias.
Alex holds a Bachelor of Science degree from Queen’s University and a Certificate in Clinical Research from Humber College.
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