PeriOperative ISchemic Evaluation-3 Trial
An international multi-centre randomized clinical trial to assess the impact of tranexamic acid (TXA) versus placebo, and to assess the impact of managing hypotension versus standard of care in patients undergoing non-cardiac surgery who are at risk of a perioperative cardiovascular event.
Multi-centre, blinded, randomized controlled trial
Primary objective is to determine the incidence of a composite of myocardial infarction, stroke and pulmonary embolism. Patients will be followed for 1 year.