Prevention of Infections in Cardiac Surgery (PICS) PREVENA Vanguard Study
A cluster-randomized factorial crossover trial, comparing antibiotic mono-prophylaxis with Cefazolin vs. dual-prophylaxis with Cefazolin plus Vancomycin and conventional wound dressing vs. PREVENA negative-pressure wound management
Randomized 2×2 factorial cluster crossover study
The main objective of this vanguard study is to test the feasibility of the study design. The primary goal of the eventual full trial is to determine the effects of dual antibiotic prophylaxis and of a negative-pressure wound management system (PREVENA) on sternal surgical site infections in patients undergoing cardiac surgery.