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TOTAL

Official Title

Randomized trial of routine aspiration ThrOmbecTomy with Percutaneous Coronary Intervention (PCI) versus PCI ALone in patients with STEMI undergoing primary PCI

Status

Completed

Overview

To determine if aspiration thrombectomy can reduce the rate of cardiovascular death, re-infarction, cardiogenic shock or new or worsening NYHA Class IV heart failure in patients with STEMI undergoing primary PCI.

Study Design

Randomized, unblinded treatment with outcomes adjudicated by assessors who will be blinded to the treatment arm.

Primary Endpoint

Primary outcome is composite of cardiovascular death, recurrent MI, cardiogenic shock, or new or worsening NHYA Class IV heart failure up to 180 days

Number of Patients

10700

Number of Sites

88

Number of Countries

20

Study Period

2010–2015

Principal Investigator

Sanjit Jolly

Program Manager

Brandi Meeks

Research Coordinator

Sadia Ahmad, Brandi Meeks

Key Publications

Jolly SS, Cairns JA, Yusuf S, Meeks B, Pogue J, Rokoss MJ, Kedev S, Thabane L, Stankovic G, Moreno R, Gershlick A, Chowdhary S, Lavi S, Niemelä K, Steg PG, Bernat I, Xu Y, Cantor WJ, Overgaard CB, Naber CK, Cheema AN, Welsh RC, Bertrand OF, Avezum A, Bhindi R, Pancholy S, Rao SV, Natarajan MK, ten Berg JM, Shestakovska O, Gao P, Widimsky P, Džavík V; TOTAL Investigators. Randomized trial of primary PCI with or without routine manual thrombectomy. N Engl J Med. 2015 Apr 9;372(15):1389-98