Randomized trial of routine aspiration ThrOmbecTomy with Percutaneous Coronary Intervention (PCI) versus PCI ALone in patients with STEMI undergoing primary PCI
To determine if aspiration thrombectomy can reduce the rate of cardiovascular death, re-infarction, cardiogenic shock or new or worsening NYHA Class IV heart failure in patients with STEMI undergoing primary PCI.
Randomized, unblinded treatment with outcomes adjudicated by assessors who will be blinded to the treatment arm.
Primary outcome is composite of cardiovascular death, recurrent MI, cardiogenic shock, or new or worsening NHYA Class IV heart failure up to 180 days
Number of Patients
Number of Sites
Number of Countries
Brandi Meeks, Susan Chrolavicius
Sadia Ahmad, Brandi Meeks
TOTAL Trial ACC Final
TOTAL – The New England Journal of Medicine
- Jolly SS, Cairns J, Yusuf S, Meeks B, Shestakovska O, Thabane L, Niemelä K, Steg PG, Bertrand OF, Rao SV, Avezum A, Cantor WJ, Pancholy SB, Moreno R, Gershlick A, Bhindi R, Welsh RC, Cheema AN, Lavi S, Rokoss M, Džavík V. Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI. Am Heart J. 2014 Mar;167(3):315-321.e1. doi: 0.1016/j.ahj.2013.12.002.