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Research

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TIMACS

Official Title

Early Versus Delayed Timing of Intervention in Patients with Acute Coronary Syndromes

Status

Completed

Overview

To compare relative efficacy, safety, and cost effectiveness of a management strategy of coronary angiography and intervention performed within 24 hours of randomization versus delayed coronary angiography and intervention in patients after 36 hours with ACS.

Study Design

Randomized, single blind (outcomes assessor), parallel group design, safety/efficacy study.

Primary Endpoint

Adjudicated. Composite of death, myocardial (re-) infarction, or stroke. Secondary Points: Death/myocardial infarction (MI)/stroke/refractory ischemia/repeat intervention at discharge/30d/180d. Death/MI/stroke at discharge/30d/180d. Major bleeding at 30d. Each component of the primary outcome individually at discharge/30d/180d.

Number of Patients

3031

Number of Sites

38

Number of Countries

14

Study Period

2003–2009

Principal Investigator

Shamir Mehta

Program Manager

Susan Chrolavicius

Research Coordinator

Craig Horsman, Barbara Jedrzejowski, Brandi Meeks

Key Publications

  • Mehta SR, Granger CB, Boden WE, Steg PG, Bassand JP, Faxon DP, Afzal R, Chrolavicius S, Jolly SS, Widimsky P, Avezum A, Rupprecht HJ, Zhu J, Col J, Natarajan MK, Horsman C, Fox KA, Yusuf S; TIMACS Investigators. Early versus delayed invasive intervention in acute coronary syndromes. N Engl J Med. 2009 May 21;360(21):2165-75. doi: 10.1056/NEJMoa0807986.