Study Type
Observational
completed
Patients with evidence of myocardial injury following non-cardiac surgery (MINS) are at increased risk of death postoperatively.
Risk stratification and selective revascularization of high-risk individuals has been shown to reduce cardiovascular events in the non-perioperative MI setting. However, its utility in MINS is not established.
In the SPECT MINS study, patients underwent Stress Single Photon Emission Computed Tomography Myocardial Perfusion Imaging (SPECT MPI) shortly after the identification of MINS, and were followed for six months post-surgery.
We evaluated whether the amount of ischemia identified on pharmacological stress testing with SPECT MPI predict death, myocardial infarction, heart failure or coronary revascularization at 6 months after surgery.
Study Design
Prospective cohort
NO. of Countries
1
NO. of Sites
1
NO. of Participants
50
Study Period
2016 - 2018
Sponsor
PHRI
PJ Devereaux
Senior Scientist
PJ Devereaux
Senior Scientist
PJ Devereaux is Senior Scientific Lead, Perioperative and Surgery, PHRI, Professor and University Scholar in the Departments of Health Research Methods, Evidence, and Impact (HEI) and Medicine at McMaster University, and Director of the Division of Cardiology at McMaster.
The focus of his clinic research is vascular complications around the time of surgery, leading several large, international RCTs and observational studies addressing this issue. He has published more than 250 peer-reviewed papers and more than 50 book chapters and editorials. He is supported by a Tier 1 Canadian Research Chair in Perioperative Medicine, and holds the Yusuf Chair in Cardiology at McMaster University.
Philip Joseph
Scientist
Philip Joseph
Scientist
Philip Joseph’s research interests include cardiovascular prevention, global health, heart failure, and cardiac imaging. He is the principal investigator for the PURE-AF substudy, and the SPECT-MINS study, an investigator in the PURE study, and the G-CHF registry. He is also the project officer for the TIPS-3 study. He has published more than 30 peer-reviewed scientific papers.
He is a fellow of the Royal College of Physicians and Surgeons of Canada, with certification in both internal medicine and cardiology. obtained his B.A.Sc at McMaster University in 2000, and his M.D. at Western University in 2004. His internal medicine (2004-2007) and cardiology (2007-2010) residencies were completed at the University of Ottawa. Subsequently, he completed additional clinical training in Nuclear Cardiology at McMaster University (2013), a M.Sc. in Health Research Methodology at McMaster (2010-13), and a post-doctoral research fellowship in PET imaging at Harvard University (2015).
Jessica Vincent
Program Director
Jessica Vincent
Program Director
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
Ingrid Copland
Senior Research Coordinator
Ingrid Copland
Senior Research Coordinator
Ingrid Copland has been working in research for McMaster University since 1991. She has been at PHRI for 23 years where she has coordinated large, international, industry and investigator initiated trials. Since 2014 she has been with the perioperative and surgery department coordinating observational, drug and device trials.
