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Research

Photo for REMIT - Sita

REMIT - Sita

Official Title

An open-label, randomized, parallel design trial to compare the efficacy of a sitagliptin-based metabolic intervention versus standard diabetes therapy in inducing remission of type 2 diabetes.

Status

Ongoing

Overview

To determine if in patients with recently-diagnosed T2DM, a 12-week course of sitagliptin, metformin, basal insulin glargine and lifestyle approaches will achieve drug-free diabetes remission in a higher proportion of patients than standard diabetes therapy at 24 weeks (3 months after the drugs are stopped). Participants will be randomized to 2 treatment groups: (a) a 12-week course of treatment with sitagliptin, metformin, insulin glargine and lifestyle therapy, and (b) standard diabetes therapy, and followed for a total of 64 weeks

Study Design

This is a multicentre, open-label, randomized controlled trial in patients with recently-diagnosed T2DM.

Primary Endpoint

The primary outcome in this trial will be diabetes remission evaluated at 24 weeks.

Number of Patients

100

Number of Sites

5

Number of Countries

1

Study Period

2016-2019

Principal Investigator

Natalia McInnes, Hertzel Gerstein

Program Manager

Tara McCready

Research Coordinator

Stephanie Hall